Pancreatic Lipase-Inhibiting Triterpenoid Saponins from Fruits of Acanthopanax senticosus
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概要
- 論文の詳細を見る
Sixteen triterpenoid saponins were isolated from the fruits of Acanthopanax senticosus, including a new compound, acanthopanaxoside E (1), which was established as 3-O-β-D-glucuronopyranosyl echinocystic acid 28-O-β-D-glucopyranoside on the basis of various spectroscopic analyses and chemical degradation. By using a pancreatic lipase-inhibiting assay system, the crude saponin fraction showed inhibitory activity on pancreatic lipase, which is a key enzyme in lipid digestion. Among the isolated compounds, silphioside F (2), copteroside B (3), hederagenin 3-O-β-D-glucuronopyranoside 6'-O-methyl ester (4) and gypsogenin 3-O-β-D-glucuronopyranoside (5) showed inhibitory activity toward pancreatic lipase with IC_<50> values of 0.22, 0.25, 0.26 and 0.29 mM, respectively, and the free carboxylic acid groups in position 28 within their chemical structures were required for enhancement of pancreatic lipase inhibition.
- 公益社団法人日本薬学会の論文
- 2007-07-01
著者
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Li Wei
Stevens Institute of Technology
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Li Wei
Faculty Of Pharmaceutical Sciences Toho University
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小池 一男
東邦大・薬
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Li W
Faculty Of Pharmaceutical Sciences Toho University
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Koike K
Faculty Of Pharmaceutical Sciences Toho University
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Koike Kazuo
Faculty Of Pharmaceutical Sciences Toho University
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LI Fang
Faculty of Pharmaceutical Sciences, Toho University
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FU Hongwei
Faculty of Pharmaceutical Sciences, Toho University
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ZHANG Qingbo
Department of Chinese Traditional Medicine, Heilongjiang Provincial Institute for Drug Control
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Li Wei
Department Of Molecular Biology Jilin University
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Li W
Laboratory Of Pharmaceutical Resource Discovery Dalian Institute Of Chemical Physics Chinese Academy
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Li Fang
Dep. Of Pharmaceutics Shenyang Pharmaceutical Univ.
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Fu Hongwei
中華人民共和国
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Zhang Qingbo
Department Of Chinese Traditional Medicine Heilongjiang Provincial Institute For Drug Control
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Koike Kazuo
Faculty Of Business Administration Hosei University
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Li Wei
Faculty Of Metallurgy And Energy Engineering Kunming University Of Science And Technology
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