Chemical Constituents from Sambucus adnata and Their Protein–Tyrosine Phosphatase 1B Inhibitory Activities

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概要

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• The MeOH extract from the whole plants of Sambucus adnata has shown significant protein–tyrosine phosphatase 1B (PTP1B) inhibitory activity. Chemical study on the extract resulted in the isolation of thirteen compounds, including a novel triterpene (1). The structure of 1 was determined to be 1α,3β-dihydroxy-urs-12-en-11-one-3-yl palmitate on the basis of extensive spectroscopic analyses. Among the isolated compounds, ursolic acid, oleanolic acid and (±)-boehmenan showed the most potent PTP1B inhibitory activity in vitro with the IC50 values of 4.1, 14.4 and 43.5 μm, respectively. The kinetic analysis indicated that (±)-boehmenan inhibits PTP1B activity in a competitive manner.

• 公益社団法人　日本薬学会の論文

著者

• Li Wei

  Stevens Institute of Technology

• Li Wei

  Faculty Of Pharmaceutical Sciences Toho University

• Li W

  Faculty Of Pharmaceutical Sciences Toho University

• Koike Kazuo

  Faculty Of Pharmaceutical Sciences Toho University

• Li Wei

  Department Of Molecular Biology Jilin University

• Asada Yoshihisa

  Faculty Of Pharmaceutical Sciences Tokyo University

• Sasaki Tatsunori

  Faculty Of Pharmaceutical Sciences Toho University

• Morimura Haruna

  Faculty of Pharmaceutical Sciences, Toho University

• Li Songpei

  Faculty of Pharmaceutical Sciences, Toho University

• Li Qin

  Laboratory Center, The Fourth Affiliated Hospital, China Medical University

• Koike Kazuo

  Faculty Of Business Administration Hosei University

• Li Wei

  Faculty Of Metallurgy And Energy Engineering Kunming University Of Science And Technology

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