The Inhibitory Effect of Intestinal Bacterial Metabolite of Ginsenosides on CYP3A Activity(Pharmacology)
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概要
- 論文の詳細を見る
The intestinal bacterial metabolites of ginsenosides are responsible for the main pharmacological activities of ginseng. The purpose of this study was to find whether these metabolites influence hepatic metabolic enzymes and to predict the potential for ginseng-prescription drug interactions. Utilizing the probe reaction of CYP3A activity, testosterone 6β-hydroxylation, the effects of derivatives of 20 (S)- protopanaxadiol and 20 (S) -protopanaxatriol families on CYP3A activity in rat liver microsomes were assayed. Our results showed that ginsenosides from the 20 (S) -protopanaxadiol and 20 (S)- protopanaxatriol family including Rb_1, Rb_2, Rc, Compound-K, Re, and Rg_1, had no inhibitory effect, whereas Rg_2, 20 (S) -panaxatriol and 20 (S) -protopanaxatriol exhibited competitive inhibitory activity against CYP3A activity in these microsomes with the inhibition constants (K_i) of 86.4±0.8 μM, 1.7±0.1 μM, and 3.2±0.2μM, respectively. This finding demonstrates that differences in their chemical structure might influence the effects of ginsenosides on CYP3A activity and that ginseng-derived products might have potential for significant ginseng-drug interactions.
- 社団法人日本薬学会の論文
- 2004-10-01
著者
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Li Wei
Stevens Institute of Technology
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Peng L
Dept.of Production Sys. Eng. Toyohashiuni. Of Tech.
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Li P
豊橋技科大 大学院
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Li Peng
Laboratory Of Pharmaceutical Resource Discovery Dalian Institute Of Chemical Physics Chinese Academy
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LIU Yong
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Acade
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YANG Ling
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Acade
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LI Wei
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Acade
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DENG Mai-Cun
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Acade
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YANG Sheng-Li
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Acade
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Deng Mai-cun
Laboratory Of Pharmaceutical Resource Discovery Dalian Institute Of Chemical Physics Chinese Academy
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Deng Mai-cun
中華人民共和国
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Yang Sheng-li
Laboratory Of Pharmaceutical Resource Discovery Dalian Institute Of Chemical Physics Chinese Academy
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Yang Sheng-li
中華人民共和国
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Li Wei
Faculty Of Pharmaceutical Sciences Toho University
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Liu Yong
Laboratory Of Pharmaceutical Resource Discovery Dalian Institute Of Chemical Physics Chinese Academy
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Yang Ling
Laboratory Of Pharmaceutical Resource Discovery Biotechnology Division Dalian Institute Of Chemical
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Li W
Faculty Of Pharmaceutical Sciences Toho University
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Li Wei
Department Of Molecular Biology Jilin University
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Li W
Laboratory Of Pharmaceutical Resource Discovery Dalian Institute Of Chemical Physics Chinese Academy
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Yang Ling
Laboratory Of Pharmaceutical Resource Discovery Dalian Institute Of Chemical Physics Chinese Academy
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Liu Yong
Laboratory Of Pharmaceutical Resource Discovery Dalian Institute Of Chemical Physics Chinese Academy
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Li Wei
Laboratory For Conservation And Utilization Of Bio-resources Key Laboratory Of Medicinal Chemistry F
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LI Peng
Laboratory of Bio-Organic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
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