Cytotoxic Polyprenylated Xanthones from the Resin of Garcinia hanburyi
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概要
- 論文の詳細を見る
Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.
- 社団法人日本薬学会の論文
- 2006-02-01
著者
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Xu Li-jia
Department Of Applied Biology & Chemical Technology The Hong Kong Polytechnic University
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YANG Ling
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Acade
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Yang Da-jian
Department Of Applied Biology & Chemical Technology The Hong Kong Polytechnic University
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Xu Li-jia
Inst. Of Medicinal Plant Dev. Chinese Acad. Of Medical Sci. Peking Union Medical Coll.
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Chen Shi-lin
Department Of Applied Biology & Chemical Technology The Hong Kong Polytechnic University
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Yang Ling
Lab. Of Pharmaceutical Resource Discovery Dalian Inst. Of Chemical Physics Chinese Acad. Of Sciences
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Yang Ling
Laboratory Of Pharmaceutical Resource Discovery Biotechnology Division Dalian Institute Of Chemical
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Song Jing
Chinese Medicine Laboratory Hong Kong Jockey Club Institute Of Chinese Medicine
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Qiao Chun-feng
Chinese Medicine Laboratory Hong Kong Jockey Club Institute Of Chinese Medicine
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XU Hong-Xi
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine
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HAN Quan-Bin
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine
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SONG Jing-Zheng
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine
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WANG Yu-Lin
Laboratory of Pharmaceutical Resources Discovery, Dalian Institute of Chemical Physics, Chinese Acad
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TSO Ting-Fai
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine
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Han Quan-bin
State Key Lab. Of Phytochemistry And Plant Resources In West China Kunming Inst. Of Botany Chinese A
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Xu Hong
Chinese Medicine Laboratory Hong Kong Jockey Club Institute Of Chinese Medicine
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Xu H‐x
Chinese Medicinal Material Research Center The Chinese University Of Hong Kong
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Wang Yu-lin
Laboratory Of Pharmaceutical Resources Discovery Dalian Institute Of Chemical Physics Chinese Academ
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Tso Ting-fai
Chinese Medicine Laboratory Hong Kong Jockey Club Institute Of Chinese Medicine
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Xu Hong-xi
Chinese Medicine Laboratory Hong Kong Jockey Club Institute Of Chinese Medicine
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