A Dammarane Glycoside Derived from Ginsenoside Rb_3
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概要
- 論文の詳細を見る
A dammarane glycoside, designated compound Mx (C-Mx), was isolated from the hydrolysate of 20 (S) -protopanaxadiol type ginsenosides containing G-Rb_3 from Panax notoginseng leaves with crude snailase. Its chemical structure was elucidated to be 20-O-β-D-xylopyranosyl(1→6)-β-D-gIucopyranosyl-20(S)-protopanaxadiol on the basis of spectral analysis. Its cytotoxicity against breast cancer cell line MCF-7 and effects on the sensitivity to doxocubicin of doxocubicin-resistant MCF-7 cells were also investigated. The new compound showed moderate cytotoxicity and partial reversal of doxocubicin resistance.
- 社団法人日本薬学会の論文
- 2005-02-01
著者
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Peng L
Dept.of Production Sys. Eng. Toyohashiuni. Of Tech.
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Li P
豊橋技科大 大学院
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Li Peng
Laboratory Of Pharmaceutical Resource Discovery Dalian Institute Of Chemical Physics Chinese Academy
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HE Kejiang
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Acade
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LIU Yong
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Acade
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YANG Yi
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Acade
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YANG Ling
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Acade
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Liu Yong
Laboratory Of Pharmaceutical Resource Discovery Dalian Institute Of Chemical Physics Chinese Academy
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Yang Ling
Laboratory Of Pharmaceutical Resource Discovery Biotechnology Division Dalian Institute Of Chemical
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He Kejiang
Laboratory Of Pharmaceutical Resource Discovery Dalian Institute Of Chemical Physics Chinese Academy
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Yang Yi
Shanghai Institute Of Ceramics Chinese Academy Of Sciences
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Yang Ling
Laboratory Of Pharmaceutical Resource Discovery Dalian Institute Of Chemical Physics Chinese Academy
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Liu Yong
Laboratory Of Pharmaceutical Resource Discovery Dalian Institute Of Chemical Physics Chinese Academy
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Yang Y
Shanghai Inst. Ceramics Chinese Adad. Sci. Shanghai Chn
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LI Peng
Laboratory of Bio-Organic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
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