Inhibitory Activity of Flavonoids and Tannins against HIV-1 Protease
スポンサーリンク
概要
- 論文の詳細を見る
Twenty-nine flavonoids and six hydrolyzable tannins were studied for their inhibitory activity against human immunodeficiency virus (HIV)-1 protease using fluorescence and HPLC assays. Among the flavonoids, flavones, flavanones, flavonols, catechols and chalcones, the flavonols were the most active category while flavanones and catechols displayed low activity. Quercetin was the most potent inhibitor of the target enzyme with an IC_<50> value of 58.8 μM, while butein and luteolin showed moderate activity. Of the hydrolyzable tannins tested, three ellagitannins which contain a hexahydroxydiphenoyl (HHDP) unit linked to the O-3 and O-6 positions of the sugar, were found to strongly inhibit HIV-1 protease. The IC_<50> values of corilagin and repandusinic acid on HIV-1 protease were 20.7 and 12.5 μM, respectively.
- 社団法人日本薬学会の論文
- 2000-09-01
著者
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FOO Lai
New Zealand Institute for Industrial Research
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BUT Paul
Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong
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But P
Department Of Biology And Institute Of Chinese Medicine The Chinese University Of Hone Kong
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Sun H‐d
State Key Laboratory Of Phytochemistry And Plant Resources In West China Kunming Institute Of Botany
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Sun Han-dong
State Key Lab. Of Phytochemistry And Plant Resources In West China Kunming Inst. Of Botany Chinese A
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Sun Han-dong
State Key Laboratory Of Phytochemistry And Plant Resources In West China Kunming Institute Of Botany
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XU Hong-Xi
Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong
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WAN Min
Faculty of Science, National University of Singapore
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DONG Hui
Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong
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XU Hong-Xi
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine
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But P
Institute Of Chinese Medicine The Chinese University Of Hong Kong
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Wan Min
Faculty Of Science National University Of Singapore
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Xu Hong
Chinese Medicine Laboratory Hong Kong Jockey Club Institute Of Chinese Medicine
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Xu H‐x
Chinese Medicinal Material Research Center The Chinese University Of Hong Kong
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Dong H
Chinese Univ. Hong Kong Hkg
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But Paul
Department Of Biochemistry The Chinese University Of Hong Kong
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Xu Hong-xi
Chinese Medicine Laboratory Hong Kong Jockey Club Institute Of Chinese Medicine
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