Total Coenzyme Q_10 Concentrations in Asian Men Following Multiple Oral 50-mg Doses Administered as Coenzyme Q_10 Sustained Release Tablets or Regular Tablets(Pharmacognosy)

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Coenzyme Q_10 (CoQ_10), a highly lipophilic compound present in the inner mitochondrial membrane, is essential for production of cellular energy in the form of ATP. CoQ_10 is used as a dietary supplement and for treatment of various cardiovascular disorders. Our goal was to compare the CoQ_10 levels in Asians following multiple oral doses administered as sustained release or regular tablets. Twenty healthy male volunteers (19-23 years old) were divided into two equal groups. Each subject in Group I received 50 mg oral doses of coenzyme Q_10 as sustained release tablets once a day for fifteen days, while subject in Group II received 50 mg doses of coenzyme Q_10 regular tablets. The CoQ_10 levels were measured by HPLC-UV (reverse phase ODS column, 10 μm, 250×4.6 mm; oven temperature 30℃). Mobile phase was constituted by methanol-ethanol 9:1 v/v. Flow rate was 1.5 ml/min and UV detection was carried out at 275 nm. Coenzyme Q_9 was used as an internal standard. CoQ_10 baseline in the morning was 0.88±0.48 mg/l. Following 1 week 50 mg/d dosing of CoQ_10, plasma CoQ_10 concentrations increased to 1.85±1.03 mg/l for sustained release tablets and up to 1.37±0.74mg/l for regular tablets. The net increment proportion in AUC for sustained release and regular tablets were 148.26±176.56%, 102.57±130.00%, respectively. Both preparations significantly increased the systemic exposure when compared to endogenous baseline.
社団法人日本薬学会の論文
2003-01-01

Total Coenzyme Q_10 Concentrations in Asian Men Following Multiple Oral 50-mg Doses Administered as Coenzyme Q_10 Sustained Release Tablets or Regular Tablets(Pharmacognosy)

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