In Vitro and in Vivo Studies on Plasma-to-Blood Ratio of Paclitaxel in Human, Rabbit and Rat Blood Fractions(Biopharmacy)

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概要

• 論文の詳細を見る

• Many pharmacokinetic studies of paclitaxel formulations with or without Cremophor (CrEL) have been performed on experimental animals. However, limited studies describe the different pharmacokinetic behaviors of paclitaxel in animals. The different distribution of drug in blood fractions may have great effect on its pharmacokinetic behaviors. Our present study was designed to study the characteristics of paclitaxel distribution in human, rabbit and rat blood, by measuring plasma-to-blood ratio (PBR) of paclitaxel in vitro and in vivo, and analyzing the results of equilibrium dialysis of paclitaxel with erythrocyte, plasma and hemoglobin. It was demonstrated that the paclitaxel PBR values in rat, unlike those in rabbit, are most significantly different from those in human, which may be due to distinct affinity of paclitaxel to blood fractions among different species. The effect of CrEL on increasing paclitaxel plasma concentration and in vitro & in vivo correlation in animal PBR values were observed. The findings in this study are of significance in the evaluation of the newly developed formulations of paclitaxel.

• 社団法人日本薬学会の論文
• 2008-06-01

著者

• Wang Li

  State Key Laboratory Of Natural And Biomimetic Drugs And School Of Pharmaceutical Sciences Peking Un

• Wang Jian-cheng

  State Key Laboratory Of Natural And Biomimetic Drugs And School Of Pharmaceutical Sciences Peking Un

• Zhang Qiang

  中華人民共和国

• Zhang Q

  State Key Laboratory Of Natural And Biomimetic Drugs And School Of Pharmaceutical Sciences Peking Un

• Zhang Q

  School Of Pharmaceutical Sciences Peking University

• Sun Jia-bei

  Department Of Pharmaceutics School Of Pharmaceutical Sciences Peking University

• Sun Jia-bei

  Department Of Pharmaceutics Peking University

• Zhang Qiang

  Department of Hepatology, Capital University of Medical Science Affiliated Beijing You An Hospital

• Zhang Xuan

  State Key Laboratory Of Natural And Biomimetic Drugs And School Of Pharmaceutical Sciences Peking Un

• LIU Xiang-Rui

  Department of Pharmaceutics, Peking University

• WU Ke-Chun

  Department of Pharmaceutics, Peking University

• HUANG Yue

  Department of Pharmaceutics, Peking University

• KE Xi-Yu

  Department of Pharmaceutics, Peking University

• WANG Jian-Cheng

  Department of Pharmaceutics, Peking University

• LU Wan-Liang

  Department of Pharmaceutics, Peking University

• ZHANG Xuan

  Department of Pharmaceutics, Peking University

• Zhang Xuan

  Department Of Human Genetics Graduate School Of Medicine University Of Tokyo

• Zhang X

  State Key Laboratory Of Natural And Biomimetic Drugs And School Of Pharmaceutical Sciences Peking Un

• Zhang Xuan

  Department Of Pharmaceutics Peking University School Of Pharmaceutical Sciences

• Liu Xiang-rui

  Department Of Pharmaceutics Peking University

• Wang Jian-cheng

  Department Of Pharmaceutics Peking University

• Lu Wan-liang

  中華人民共和国

• Zhang Qiang

  Department Of Cardiology Beijing Anzhen Hospital Capital Medical University

• Ke Xi-yu

  Department Of Pharmaceutics Peking University

• Huang Yue

  Department Of Pharmaceutics Peking University

• Huang Yue

  Department Of Histology And Embryology Third Military Medical University

• Wu Ke-chun

  Department Of Pharmaceutics Peking University

• Lu Wan-liang

  Department Of Pharmaceutics School Of Pharmaceutical Sciences Peking University:state Key Laboratory

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