Antidepressant-Like Effects of Psoralen Isolated from the Seeds of Psoralea corylifolia in the Mouse Forced Swimming Test(Pharmacology)
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概要
- 論文の詳細を見る
The forced swimming test (FST) is suggested to produce abnormalities in the serotonergic and hypothalamic-pituitary-adrenal (HPA) axis systems. Therefore, compounds that attenuate these neurobiological alterations may have potential as antidepressants. The behavioral and biochemical effects of psoralen, a major furocoumarin isolated from Psoralea corylifolia, were investigated in the FST model of depression in male mice. Psoralen significantly reduced immobility and increased swimming without altering climbing in the mouse FST. Psoralen remarkably reversed FST-induced alterations in serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in frontal cortex and hippocampus in mice. Furthermore, psoralen attenuated FST-induced elevations in serum corticotropin-releasing factor (CRF) and corticosterone concentrations to normalize the HPA axis activity. These results suggested that psoralen possessed potent antidepressant-like properties which were at least in part mediated by improving the abnormalities in the serotonergic and the HPA axis systems.
- 社団法人日本薬学会の論文
- 2008-06-01
著者
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Xu Qun
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University
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Yi Li-tao
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University
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Jiang Fu-xin
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University
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Kong Ling-dong
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University:cent
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Lu Xiao-bo
Center For Emerging Infectious Diseases Faculty Of Medicine The Chinese University Of Hong Kong
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Qiao Chun-feng
Chinese Medicine Laboratory Hong Kong Jockey Club Institute Of Chinese Medicine
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PAN Ying
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
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LI Yu-Cheng
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
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MO Shi-Fu
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
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XU Hong-Xi
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine
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KUNG Hsiang-Fu
Center for Emerging Infectious Diseases, Faculty of Medicine, The Chinese University of Hong Kong
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Kung Hsiang-fu
Center For Emerging Infectious Diseases Faculty Of Medicine The Chinese University Of Hong Kong
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Xu Hong
Chinese Medicine Laboratory Hong Kong Jockey Club Institute Of Chinese Medicine
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Xu H‐x
Chinese Medicinal Material Research Center The Chinese University Of Hong Kong
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Pan Ying
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University
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Mo Shi-fu
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University:chin
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Mo Shi-fu
State Key Laboratory Of Pharmaceutical Biotechnology Nanjing University
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Li Yu-cheng
State Key Laboratory Of Pharmaceutical Biotechnology School Of Life Sciences Nanjing University
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Kong Ling-dong
State Key Laboratory Of Pharmaceutical Biotechnology Nanjing University
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Xu Hong-xi
Chinese Medicine Laboratory Hong Kong Jockey Club Institute Of Chinese Medicine
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