Inhibition of Immediate Allergic Reactions by Ethanol Extract from Plumbago zeylanica Stems (Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
The antiallergic properties of the 70% ethanol extract from Plumbago zeylanica stems (EPZ) were investigated in the present study. The extract (500, 1000 mg/kg, p. o.) dose-dependently inhibited systemic anaphylactic shock induced by compound 48/80 in mice, reduced homologous passive cutaneous anaphylaxis and skin reactions induced by histamine or serotonin in rats, significant differences were observed at the dose of 1000 mg/kg. In vitro, EPZ (5, 20, 50μg/ml) concentration-dependently reduced histamine release from rat peritoneal mast cells caused by compound 48/80 and antigen. EPZ (50 μg/ml) markedly increased intracellular cAMP content of rat mast cells. These findings demonstrate that EPZ inhibits mast cell-dependent immediate allergic reactions, which is probably mediated by reducing the release of mediators such as histamine from mast cells via elevating intracellular cAMP level and weakening the inflammatory action of mediators.
- 社団法人日本薬学会の論文
- 2004-03-01
著者
-
Hou Li-fei
中華人民共和国
-
BUT Paul
Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong
-
CHAN Yiu-Pong
Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong
-
Chan Y‐p
Department Of Biology And Institute Of Chinese Medicine The Chinese University Of Hone Kong
-
Chan Yiu-pong
Department Of Biology And Institute Of Chinese Medicine The Chinese University Of Hong Kong
-
Dai Yue
School Of Traditional Chinese Medicine Shenyang Pharmaceutical Univ.
-
But P
Department Of Biology And Institute Of Chinese Medicine The Chinese University Of Hone Kong
-
DAI Yue
Denartment of Pharmacology of Chinese Materia Medica, China Pharmaceutiral University
-
HOU Li-Fei
Denartment of Pharmacology of Chinese Materia Medica, China Pharmaceutiral University
-
CHENG Ling
Department of Biology and Institute of Chinese Medicine, The Chinese University of Hone Kong
-
Yuan D
Department Of Traditional Chinese Medicine Shenyang Pharmaceutical University
-
Yuan Dan
Department Of Traditional Medicinal Science Hokkaido College Of Pharmacy
-
But P
Institute Of Chinese Medicine The Chinese University Of Hong Kong
-
Dai Y
School Of Traditional Chinese Medicine Shenyang Pharmaceutical Univ.
-
Hou Li-fei
Denartment Of Pharmacology Of Chinese Materia Medica China Pharmaceutiral University
-
But Paul
Department Of Biochemistry The Chinese University Of Hong Kong
-
Yuan D
Shenyang Pharmaceutical Univ. Shenyang Chn
-
Cheng Ling
Department Of Biology And Institute Of Chinese Medicine The Chinese University Of Hone Kong
-
Yuan Dan
Department Of Traditional Chinese Medicines Shenyang Pharmaceutical University
関連論文
- Structures of Acetylated Oleanane-Type Triterpene Saponins, Rarasaponins IV, V, and VI, and Anti-hyperlipidemic Constituents from the Pericarps of Sapindus rarak
- Medicinal Flowers. XXIII. New Taraxastane-Type Triterpene, Punicanolic Acid, with Tumor Necrosis Factor-α Inhibitory Activity from the Flowers of Punica granatum
- Studies on Kochiae Fructus. V. Antipruritic Effects of Oleanolic Acid Glycosides and the Structure-Requirement
- Studies on Kochiae Fructus IV. Anti-Allergic Effects of 70% Ethanol Extract and Its Component, Momordin Ic from Dried Fruits of Kochia scoparia L.
- Studies on Kochiae Fructus III. Antinociceptive and Antiinflammatory Effects of 70% Ethanol Extract and Its Component, Momordin Ic from Dried Fruits of Kochia scoparia L.
- Studies on Kochiae Fructus. II. On the Saponin Constituents from the Fruit of Chinese Kochia scoparia (Chenopodiaceae) : Chemical Structures of Kochianosides I, II, III, and IV
- Antipruritic and Antiinflammatory Effects of Aqueous Extract from Si-Wu-Tang
- Inhibition of Immediate Allergic Reactions by Ethanol Extract from Plumbago zeylanica Stems (Pharmacognosy)
- Inhibitory Effects of Thunberginols A, B, and F on Degranulations and Releases of TNF-α and IL-4 in RBL-2H3 Cells(Pharmacognosy)
- Inhibitory Activity of Flavonoids and Tannins against HIV-1 Protease
- Antiallergic and Anti-inflammatory Properties of the Ethanolic Extract from Gleditsia sinensis
- A New Cytotoxic Polyhydroxysterol from Soft Coral Sarcophyton trocheliophorum
- Selaginellin A and B, Two Novel Natural Pigments Isolated from Selaginella tamariscina
- Uncinoside A and B, Two New Antiviral Chromone Glycosides from Selaginella uncinata
- An Anti-aldosteronic Diuretic Component (Drain dampness) in Polyporus Sclerotium (猪苓)
- Pharmacological Properties of Traditional Medivines. XXV. Effects of Ephedrine, Amygdalin, Glycyrrhizin, Gypsum and Their Combinations on Body Temperature and Body Fluid
- Pharmacological Properties of Traditional Medicines. XXIV. Classification of Antiasthmatics Based on Constitutional Predispositions
- In Vitro Evaluation of Secoiridoid Glucosides from the Fruits of Ligustrum lucidum as Antiviral Agents
- A Novel 1 : 1 Complex of Potassium Mikanin-3-O-sulfate with Methanol
- Antioxidative Glucosides from the Fruits of Ligustrum lucidum
- Antiviral Amentoflavone from Selaginella sinensis
- A New Anti-HIV Triterpene from Geum japonicum
- Inhibition of Experimental Allergic Rhinitis by the n-Butanol Fraction from the Anomalous Fruits of Gleditsia sinensis
- Saponins of Plants of Panax Species Collected in Central Nepal and Their Chemotaxonomical Significance. II
- A New Experimental Device for the Measurement of Moisture Emission and Heat Release from Respiratory Organs and Body Surface
- Quantitative Analysis of the Marker Compounds in Salvia miltiorrihiza Root and Its Phytomedicinal Preparations
- Pharmacokinetics of kakkalide and its main metabolites in rat plasma determined by HPLC-DAD and LC-MS^n