An Anti-aldosteronic Diuretic Component (Drain dampness) in Polyporus Sclerotium (猪苓)
スポンサーリンク
概要
- 論文の詳細を見る
Polyporus Sclerotium (猪苓), botanically from the Polyporus umbellatm (PERS.) FRIES, was traditionally used for the purpose of promoting diuresis. The present study investigated the diuretic effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) which is a maker component according to the chemical assay for its quality standardization. It resulted in a reversion to ordinary value of the urinary ratio of Na/K in deoxycoricosterone acetate (DOCA)-treated and adrenalectomized rats, although it had no this effect on the Na or K contents as well as Na/K value both in normal rats and in adrenalectomized rats without DOCA. These data indicate that ergone possesses an anti-aldosteronic diuretic effect. Moreover, it was identified in the blood and bile of rats after its administration to the gastrointestinal tract. The above results demonstrate that it is an active component of Polyporus Sclerotium.
- 公益社団法人日本薬学会の論文
- 2004-06-01
著者
-
Kano Y
Hokkaido Coll. Pharmacy Otaru Jpn
-
Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
-
Kano Y
Department Of Traditional Medicinal Science Hokkaido College Of Pharmacy
-
Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
-
Yuan D
Department Of Traditional Chinese Medicine Shenyang Pharmaceutical University
-
Yuan Dan
Department Of Traditional Medicinal Science Hokkaido College Of Pharmacy
-
Yuan Dan
Department Of Traditional Chinese Medicinal Sciences Shenyang Pharmaceutical University
-
MAKINO Toshiaki
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
-
Katagiri Y
Hokkaido Institute Of Pharmaceutical Sciences
-
KOMATSU Ken-ichi
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
-
Mori J
Department Of Pharmaceutical Research Lead Chemical Co. Ltd.
-
MORI Junna
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
-
KOMATSU Ken-ich
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
-
Yuan D
Shenyang Pharmaceutical Univ. Shenyang Chn
-
Makino T
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
-
Komatsu Ken-ich
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
-
Makino T
Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sci. Nagoya City Univ.
-
Makino Toshiaki
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
-
Mori J
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
-
Kano Yoshihiro
Iskra Industry Co. Ltd.
-
Komatsu Ken-ichi
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
-
Makino Toshiaki
Department Of Chemistry Faculty Of Science Okayam University Of Science
-
Makino Taketoshi
R&d Center Sunstar Inc.
-
Makino Toshiaki
Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City Univ.
-
Yuan Dan
Department Of Traditional Chinese Medicines Shenyang Pharmaceutical University
-
Kano Yoshihiro
Department Of Gastroenterological Surgery Osaka University Graduate School Of Medicine
関連論文
- Structures of Acetylated Oleanane-Type Triterpene Saponins, Rarasaponins IV, V, and VI, and Anti-hyperlipidemic Constituents from the Pericarps of Sapindus rarak
- Medicinal Flowers. XXIII. New Taraxastane-Type Triterpene, Punicanolic Acid, with Tumor Necrosis Factor-α Inhibitory Activity from the Flowers of Punica granatum
- Liposomalization of Lactoferrin Enhanced It's Anti-inflammatory Effects via Oral Administration(Biopharmacy)
- Studies on Kochiae Fructus. V. Antipruritic Effects of Oleanolic Acid Glycosides and the Structure-Requirement
- Studies on Kochiae Fructus IV. Anti-Allergic Effects of 70% Ethanol Extract and Its Component, Momordin Ic from Dried Fruits of Kochia scoparia L.
- Studies on Kochiae Fructus III. Antinociceptive and Antiinflammatory Effects of 70% Ethanol Extract and Its Component, Momordin Ic from Dried Fruits of Kochia scoparia L.
- Studies on Kochiae Fructus. II. On the Saponin Constituents from the Fruit of Chinese Kochia scoparia (Chenopodiaceae) : Chemical Structures of Kochianosides I, II, III, and IV
- Antipruritic and Antiinflammatory Effects of Aqueous Extract from Si-Wu-Tang
- Effect of Oral Treatment of Perilla frutescens and Its Constituents on Type-I Allergy in Mice
- Inhibition of Immediate Allergic Reactions by Ethanol Extract from Plumbago zeylanica Stems (Pharmacognosy)
- Inhibitory Effects of Thunberginols A, B, and F on Degranulations and Releases of TNF-α and IL-4 in RBL-2H3 Cells(Pharmacognosy)
- Antioxidant and Antiviral Activities of Plastoquinones from the Brown Alga Sargassum micracanthum, and a New Chromene Derivative Converted from the Plastoquinones(Pharmacognosy)
- Effects of Kangen-karyu on Coagulation System and Platelet Aggregation in Mice
- Metabolic Degradation of [6]-Gingerol in Rat Jejunal Mucosa
- In Situ Jejunal Absorption of [6]-Gingerol in Rats
- Effect of Absorption Enhancers on the Permeation of Morphine in the Isolated Rectum of Rabbit
- A Minor Possibility of Pharmacokinetic Interaction between Enoxacin and Fenbufen in Rats
- Comparison of Saliva Stimulation Methods for Noninvasive Therapeutic Drug Monitoring by Using Saliva Samples
- A Minor Possibility of Pharmacokinetic Interaction between Norfloxacin and Fenbufen in Rats
- Simplified Procedures for the Simultaneous Determination of Enoxacin, Fenbufen and Felbinac in Rat Plasma by High-performance Liquid Chromatography
- Stability and Clinical Application of Tetracaine-Glycerin Injection for Nerve Blocks
- BLEOMYCIN-LIPIODOL SUSPENSION FOR INTRALYMPHATIC ADMINISTRATION IN ESOPHAGEAL CANCER
- Pharmacological Properties of Traditional Medicine (XXXII) : Protective Effects of Hangeshashinto and the Combinations of Its Major Constituents on Gastric Lesions in Rats(Pharmacognosy)
- Antiviral Sulfated Polysaccharide from Navicula directa, a Diatom Collected from Deep-Sea Water in Toyama Bay(Pharmacognosy)
- New Chromane Derivatives Isolated from the Brown Alga, Sargassum micracanthum
- Effects of Plastoquinones from the Brown Alga Sargassum micracanthum and a New Chromene Derivative Converted from the Plastoquinones on Acute Gastric Lesions in Rats(Pharmacognosy)
- A Synthetic Study on Antiviral and Antioxidative Chromene Derivative
- New Plastoquinones Isolated from the Brown Alga, Sargassum micracanthum
- Suppressive effects of Sairei-to on mesangial proliferation in a rat model of glomerulonephritis
- Suppressed Permeation of Linoleic Acid in a Liposomal Formulation through Reconstructed Skin Tissue(Biopharmacy)
- Skin Whitening Effect of Linoleic Acid Is Enhanced by Liposomal Formulations (Biopharmacy)
- Periodic Secretion of Adrenocorticotropin in a Patient with Cushing's Disease Manifested during Pregnancy
- Abrupt Enlargement of Adrenal Incidentaloma : A Case of Isolated Adrenal Metastasis
- Suppressive Effects of Perilla frutescens on Mesangioproliferative Glomerulonephritis in Rats
- Effect of Perilla frutescens Extract on Nitric Oxide Production by Cultured Murine Mesangial Cells
- Basic study and clinical practice of Kampo medicines in chronic kidney disease (CKD) : chronic glomerulonephritis and nephrosclerosis
- Pharmacological Properties of Traditional Medicines. XXII. Pharmacokinetic Study of Mulberroside A and Its Metabolites in Rat
- Pharmacological Properties of Traditional Medicines (XXI) : Analysis of Plasma, Urine and Bile of Rats after Oral Administration of Water Extract of Mori Cortex
- Enzymatically Modified Isoquercitrin, α-Oligoglucosyl Quercetin 3-O-Glucoside, Is Absorbed More Easily than Other Quercetin Glycosides or Aglycone after Oral Administration in Rats
- Inhibitory Activities of Plastoquinones and Chromene Derivative from a Brown Alga Sagassum micracanthum on Bone Resorption(Pharmacognosy)
- Antiviral Targets of a Chromene Derivative from Sargassum micracanthum in the Replication of Human Cytomegalovirus(Microbiology)
- An Anti-aldosteronic Diuretic Component (Drain dampness) in Polyporus Sclerotium (猪苓)
- Pharmacological Properties of Traditional Medicine (XXIX) : Effect of Hange-shashin-to and the Combinations of Its Herbal Constituents on Rat Experimental Colitis(Pharmacognosy)
- Anti-stress Effects of 3,4,5-Trimethoxycinnamic Acid, an Active Constituent of Roots of Polygala tenuifolia (Onji)(Pharmacognosy)
- Interaction between 3,4,5-trimethoxycinnamic acid and spinosin on pentobarbital-induced sleeping time in mice
- Effect of Moisture on Impact Toughness of Sugar-Coated Tablets Manufactured by the Dusting Method
- Improvement of Impact Toughness of Sugar-Coated Tablets Manufactured by the Dusting Method
- High-Performance Liquid Chromatographic Assay of Clonazepam in Human Plasma Using a Non-porous Silica Column(Analytical Biochemistry)
- High-performance liquid chromatographic assay of zonisamide in human plasma using a non-porous silica column
- Pharmacological properties of traditional medicine (XXXI) : Anxiolytic effect of Hangeshashinto and the combinations of its major constituents on rat experimental colitis
- Pharmacological Properties of Traditional Medicines (XXVII). Interaction between Ephedra Herb and Gypsum under Hyperthermal Conditions in Rats
- Pharmacological Properties of Traditional Medivines. XXV. Effects of Ephedrine, Amygdalin, Glycyrrhizin, Gypsum and Their Combinations on Body Temperature and Body Fluid
- Pharmacological Properties of Traditional Medicines. XXIV. Classification of Antiasthmatics Based on Constitutional Predispositions
- Chemoprevention of Tumor Metastasis by Liposomal β-Sitosterol Intake(Molecular and Cell Biology)
- Roles of Coagulation Pathway and Factor Xa in the Progression of Diabetic Nephropathy in db/db Mice
- Pharmacological Properties of Traditional Medicine(30)Effects of Gyokuheifusan (玉屏風散) on Murine Antigen-Specific Antibody Production
- Preventive and Curative Effects of Gyokuheifu-san, a Formula of Traditional Chinese Medicine, on Allergic Rhinitis Induced with Japanese Cedar Pollens in Guinea Pig (Pharmacognosy)
- Pharmacognostical and Botanical Studies on the Crude Drugs in Hokkaido-7-Cultivation of Corydalis ambigua Cham.et Schlecht-3-Seasonal Growth of Tubers and Their Alkaloid Contents
- Pharmacognostical and Botanical Studies on the Crude Drugs in Hokkaido-4-Determination of Tertiary Alkaloids in Corydalis ambigua by High Performance Liquid Chromatography
- A New Experimental Device for the Measurement of Moisture Emission and Heat Release from Respiratory Organs and Body Surface
- Pharmacological Properties of Traditional Medicines 23.Searching for Active Compounds in the Blood and Bile of Rats after Oral Administrations of Extracts of Sansohnin(酸棗仁)
- Quantitative Analysis of the Marker Compounds in Salvia miltiorrihiza Root and Its Phytomedicinal Preparations
- Processed Aconite Root Prevents Cold-Stress-Induced Hypothermia and Immuno-Suppression in Mice
- Two new monoterpenes from Sibiraea angustata
- Pharmacological Properties of Traditional Medicines(26)Effects of Sansohnin-to(酸棗仁湯)on Pentobarbital Sleep in Stressed Mice
- Pharmacokinetic Interactions between Japanese Traditional Kampo Medicine and Modern Medicine (IV). Effect of Kamisyoyosan and Tokisyakuyakusan on the Pharmacokinetics of Etizolam in Rats(Pharmacognosy)
- Pharmacokinetic Interactions between Japanese Traditional Medicine (Kampo) and Modern Medicine (III). : Effect of Sho-seiryu-to on the Pharmacokinetics of Azelastine Hydrochloride in Rats (Pharmacognosy)
- Rotational Isomerism Involving an Acetylenic Carbon II : Effect of 1-Halogen Substituents on Rotamer Population and Rotational Barrier around C(sp)-C(sp^3) Bonds in Bis(9-triptycyl)ethynes^1
- Analysis and Bioactive Evaluation of the Compounds Absorbed into Blood after Oral Administration of the Extracts of Vaccinium vitis-idaea in Rat(Pharmacognosy)
- Comparison of the contents of kampo decoctions containing ephedra herb when prepared simply or by re-boiling according to the traditional theory
- Rotational Isomerism Involving an Acetylenic Carbon VI. Syntheses, Structures, and Dynamic Stereochemistry of Bis(1-phenyl-9-anthryl)ethynes : Highly Restricted Rotation about Acetylenic Axis in Acyclic Diarylethynes
- Effect of Bakumijiogan, an Herbal Formula in Traditional Chinese Medicine, on Atopic Dermatitis-Like Skin Lesions Induced by Mite Antigen in NC/Jic Mice(Pharmacognosy)
- Does a Kampo Medicine Containing Schisandra Fruit Affect Pharmacokinetics of Nifedipine Like Grapefruit Juice?(Pharmacognosy)
- Pharmacological Properties of Traditional Medicines (XXI) : Analysis of Plasma, Urine and Bile of Rats after Oral Administration of Water Extract of Mori Cortex
- Studies on Distribution of ^3H-Dimethylesculetin and its Excretion in Rats
- Pharmacokinetics of kakkalide and its main metabolites in rat plasma determined by HPLC-DAD and LC-MS^n
- Capillary GC-MS Analysis of Volatile Components in Japanese Gingers
- HPLC Analysis of Gingerols and Diterpenes in Japanese Gingers
- On the Evaluation of the Preparation of Chinese Medicinal Prescriptions (V) : Diterpenes from Japanese Ginger "Kintoki"
- Simultaneous and Quantitative Analysis of Alkaloids in Evodia Fruit(呉茱萸)
- Pharmacological Properties of Galenical Preparation-13-Metabolites in Rat Urine of Orally Administered Evodia Fruits(呉茱萸)Extract
- Pharmacognostical and Botanical Studies on the Crude Drugs in Hokkaido (V) : Relation between Corydaline and Dehydrocorydaline (DHC) in Corydalis ambigua Tubers
- Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by the DDAH-ADMA-NO pathway
- Cancer stem cell theory in gastrointestinal malignancies : recent progress and upcoming challenges
- Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by the DDAH-ADMA-NO pathway