Inhibitory Activities of Plastoquinones and Chromene Derivative from a Brown Alga Sagassum micracanthum on Bone Resorption(Pharmacognosy)
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概要
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We evaluated inhibitory effects of plastoquinones (1, 2) and chromene derivative (3) from the methanol extract of Sargassum micracanthum on the differentiation of osteoclast progenitors into osteoclast-like cells (OCLs), bone-resorbing activity and the survival of OCLs. When OCL formation was investigated using osteoclast progenitor cells obtained from macrophage-colony stimulating factor (M-CSF)-treated mouse bone marrow, 1-3 inhibited dose-dependently OCL formation at the concentrations of 3-10μM, the order of inhibitory potency being 1>3>2. In addition, they suppressed dose-dependently the pit formation induced by OCL on dentine slices, the order of inhibitory potency being 1>3>2. The survival of OCLs was inhibited by about 35, 45 and 60% in the presence of 6μM of 2, 3 and 1, respectively. These results suggest that the inhibitory effects of the three compounds on the differentiation, pit formation and the survival of OCLs might contribute to the suppression of bone resorption.
- 公益社団法人日本薬学会の論文
- 2006-09-01
著者
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Hayashi Toshimitsu
Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
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SAITO Haruo
Department of Radiological Technology, School of Health Sciences, Faculty of Medicine
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Miyahara Tatsuro
Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Mori Jun
Department Of Pharmaceutical Research Lead Chemical Co. Ltd.
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Mori Jun
The Institute Of Scientific And Industrial Research Osaka University
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Saito Haruo
Department Of Pharmaceutical Research Lead Chemical Co. Ltd.
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Saito H
Toyama Prefectural Institute For Pharmaceutical Research
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OCHIAI Hiroshi
Graduate School of Pharmaceutical Sciences, Hokkaido University
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Hayashi Toshimitsu
Graduate School Of Medicine And Pharmaceutical Science For Research University Of Toyama
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Hayashi T
Faculty Of Pharmaceutical Sciences Josai University
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Mori J
Department Of Pharmaceutical Research Lead Chemical Co. Ltd.
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KOMAI Eiko
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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MORI Jun
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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OBI Nobuko
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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Komai Eiko
Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Obi Nobuko
Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Ochiai Hiroshi
Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Saito Haruo
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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