Characterization of Structures and Antiviral Effects of Polysaccharides from Portulaca oleracea L.
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概要
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Three polysaccharides including a neutral polysaccharide (RN), an acidic polysaccharide (RA) and a pectic polysaccharide (RP) were isolated from aerial part of Portulaca oleracea L. and evaluated for their anti-herpes simplex virus type 2 (HSV-2) and anti-influenza A virus (IFV-A). RN was found to consist of glucose (Glc), mannose (Man) and arabinose (Ara) with small amounts of galactose (Gal), and identified to be an arabinoglucomannan. RA was mainly composed of Gal and Ara with a small proportion of glucuronic acid (GlcA). It was characterized as a type II arabinogalactan (AGII), which consisted of a 1,3-, 1,6- and 1,3,6-linked galactopyranosyl (Galp) and non-reducing terminal and 1,5-linked arabinofuranosyl (Araf) residues. RP was deduced to be a pectin, which consisted of a predominant amount of galacturonic acid (GalA) with small amounts of Gal, rhamnose (Rha) and Ara. The GalA residues were found to be highly methyl-esterified and partially acetylated. Results of antiviral tests showed that only RP had anti-HSV-2 activity. Furthermore, its anti-HSV-2 target was elucidated to be the step of virus penetration into host cells. No marked virucidal activity of RP was observed.
著者
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Hayashi Kyoko
Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
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Hayashi Toshimitsu
Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
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Lee Jung-Bum
Graduate School of Medicine and Pharmaceutical Sciences for Research
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Lee Jung-bum
富山大学 大学院医学薬学研究部
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Lee Jung-bum
Faculty Of Pharmaceutical Sciences University Of Toyama
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Lee J‐b
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical Uni
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Hayashi Kyoko
Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Dong Cai-Xia
Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama
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Hayashi Toshimitsu
Graduate School Of Medicine And Pharmaceutical Science For Research University Of Toyama
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Hayashi K
Graduate School Of Medicine And Pharmaceutical Sciences For Research University Of Toyama
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Hayashi Kyoko
Graduate School Of Medicine And Pharmaceutical Sciences For Research University Of Toyama
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Hayashi Toshimitsu
Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama
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