Development of a Membrane Fusible Drug Carrier from Erythrocytes by the Spontaneous Transfer of Viral Fusion Protein from Influenza Virus-Infected Cells

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概要

• 論文の詳細を見る

• In order to develop a membrane fusible drug carrier from human erythrocytes, we attempted the reconstitution of influenza virus fusion protein hemagglutinin (HA) to an erythrocyte membrane. In this study, we succeeded in the preparation of HA-reconstituted erythrocytes (HA-erythrocytes) by the incubation of erythrocytes with influenza virus-infected CV-1 cells, and confirmed the ability of HA-erythrocytes to fuse with the cell membrane. Furthermore, by using an HA-reconstituted ghost (HA-ghost), which entrapped fluorescent-labeled ovalbumin, 25% of the protein was incorporated into cells through the fusion of the HA-ghost with the cell membrane.

• 公益社団法人日本薬学会の論文
• 1997-05-15

著者

• Hayashi Kyoko

  Faculty Of Medicine Toyama Medical And Pharmaceutical University

• Kogure Kentaro

  Dep. Of Biophysical Chemistry Kyoto Pharmaceutical Univ.

• Kogure K

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:(present Address)fac

• Kogure Kentaro

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• UENO Masaharu

  Faculty of Pharmaceutical Sciences, University of Toyama

• Itoh Taku

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Okuda O

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 奥田 修

  Faculty Of Pharmaceutical Sciences Osaka University

• Ueno Masaharu

  Faculty Of Phamaceutical Sciences Toyama Medical And Pharmaceutical University

• OKUDA Otomo

  Faculty of Pharmaceutical Sciences Toyama Medical and Pharmaceutical University

• Hayashi K

  Graduate School Of Medicine And Pharmaceutical Sciences For Research University Of Toyama

• Ueno M

  Fac. Of Pharmaceutical Sciences Univ. Of Toyama

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