Size Control of Mixed Egg Yolk Phosphatidylcholine (EggPC)/Oleate Vesicles
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概要
- 論文の詳細を見る
The size distribution after addition of oleate surfactant to preformed Egg yolk phosphatidylcholine (EggPC) vesicles was investigated by gel filtration chromatography combining with dynamic light scattering. Phospholipid and oleate concentration, fluorescence intensity and size of the vesicles were measured for each elution fraction. The spontaneous vesiculation of oleate at pH 8.5 was accelerated in the presence of preformed EggPC vesicles. The size distribution of newly formed vesicles was dependent on the preformed vesicular size. For example, oleate addition to large preformed vesicles (230 nm) resulted in altering of vesicles to both larger and smaller than preformed ones, while addition of oleate to small preformed vesicles (50 nm) led to the formation of only larger vesicles without exhibition of newly small vesicles. The combinations of gel filtration chromatography and dynamic light scattering could provide more detailed insight into the size change of newly formed vesicles.
- 公益社団法人日本薬学会の論文
- 2004-09-01
著者
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Chungcharoenwattana S
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Chungcharoenwattana Suparpun
Faculty Of Phamaceutical Sciences Toyama Medical And Pharmaceutical University
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Ueno Masaharu
Faculty Of Phamaceutical Sciences Toyama Medical And Pharmaceutical University
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