Characteristics of the Membrane Permeability of Temperature-Sensitive Liposome.
スポンサーリンク
概要
- 論文の詳細を見る
The relationship between the temperature-sensitivity of the release of an entrapped drug from liposome as well as the type of drug or liposome is discussed. The drug release from DPPC liposome (dipalmitoylphosphatidylcholine liposome) has been confirmed to increase abruptly near its phase-transition temperature for both low-molecular-weight compouds (such as calcein) and high-molecular-weight compounds (such as dextran). The amount of temperature-sensitive calcein released from the liposomes was dependent on the method of liposome preparation: that is, the release from REV (reverse phase evaporated vesicle) was the highest; next was that from LUV (large unilamellar vesicle prepered by detergent removal method), and lowest was from SUV (small unilamellar vesicle prepared by an ultrasonication method). In order to examine the size effect of liposomes on temperature-sensitive drug release, REV was fractionated into three groups according to their average sizes and calcein release for each group was investigated. The temperature at which calcein release showed a maximum was almost the same in each of three groups; while as the average liposome size of a group was larger, the initial rate of calcein release became higher and the temperature at which calcein release began became lower. The amount of release of a entrapped drug was primarily dependent on the molecular weight of the drug, in spite of the variety of drugs investigated.
- 公益社団法人 日本化学会の論文
著者
-
HORIKOSHI Isamu
Department of Hospital Pharmacy Toyama Medical and Pharmaceutical University
-
Ueno Masaharu
Faculty Of Phamaceutical Sciences Toyama Medical And Pharmaceutical University
-
Ueno Masaharu
Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University
-
Yoshida Shoshin
Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University
関連論文
- Process of Destruction of Large Unilamellar Vesicles by a Zwitterionic Detergent, CHAPS : Partition Behavior between Membrane and Water Phases
- Difference between Yeast and Bovine Mitochondrial ADP/ATP Carriers in Terms of Conformational Properties of the First Matrix Loop as Deduced by Use of Copper-o-phenanthroline(Molecular and Cell Biology)
- Pharmacokinetics of Two Rectal Dosage Forms of Ketoprofen in Patients after Anal Surgery
- Delivery of Condensed DNA by Liposomal Non-viral Gene Delivery System into Nucleus of Dendritic Cells(Biopharmacy)
- Effects of Incorporation of Various Amphiphiles into Recipient Liposome Membraneson Inter-Membrane Protein Transfer
- Pharmacokinetic Study of Taxol-Loaded Poly(lactic-co-glycolic acid) Microspheres Containing Isopropyl Myristate after Targeted Delivery to the Lung in Mice
- Preparation and Characterization of Poly(lactic-co-glycolic acid)Microspheres for Targeted Delivery of a Novel Anticancer Agent, Taxol
- In Vitro and In Vivo Evaluation of Chitosan Microspheres Containing Cisplatin : Hepatic Artery Chemo-embolization in Dogs
- Factors Causing Age-Dependent Changes in Phenytoin Tissue and Serum Binding in Rats
- AGE-DEPENDENT CHANGES IN PHENYTOIN TISSUE BINDINGS IN RATS : COMPARISON BETWEEN IN VIVO AND IN VITRO TISSUE-TO-BLOOD PARTITION COEFFICIENTS (K_p VALUES) OF PHENYTOIN
- AGE-DEPENDENT CHANGE IN WARFARIN DISTRIBUTION VOLUME IN RATS : EFFECT OF CHANGE IN EXTRACELLULAR WATER VOLUME
- AGE-DEPENDENT CHANGES IN PHENYTOIN TISSUE DISTRIBUTION IN RATS
- AGE-DEPENDENT CHANGES IN WARFARIN TISSUE DISTRIBUTION
- Pharmacokinetics of a Chinese Traditional Medicine, Denshensu (3,4-Dihydroxyphenyllactic Acid), in Rabbits Using High-Performance Liquid Chromatography
- Rectal Absorption of Ozagrel from a Suppository Containing Its Commercial Tablet in Health Human Subjects
- Rectal Absorption of a New Thromboxane Synthetase Inhibitor, DP-1904, from Witepsol Suppositories in Rabbits
- Pharmacokinetic and Pharmacodynamic Modeling of a Thromboxane Synthetase Inhibitor, Ozagrel, in Human
- Pharmacokinetic and Pharmacodynamic Modeling of a Novel Thromboxane Synthetase Inhibitor, DP-1904, in Human
- Physical Properties of Phosphatidyicholine Vesicles Containing Small Amount of Sodium Cholate and Consideration on the Initial Stage of Vesicle Solubilization
- Photo-Stability of Drugs in Enteral Hyperalimentation Solutions and Its Influence on the Dose Given by a Continuous Infusion
- Evaluation of Dose of Unstable Drug Administered by Infusion
- DISPOSITION OF SALICYLIC ACID IN ANALBUMINEMIC RATS
- Development of a Membrane Fusible Drug Carrier from Erythrocytes by the Spontaneous Transfer of Viral Fusion Protein from Influenza Virus-Infected Cells
- Microdialysis Assessment of Fibrin Glue Containing Sodium Alginate for Local Delivery of Doxorubicin in Tumor-Bearing Rats
- Disposition of Liposomal Cepharanthine after Intraperitoneal Administration in Mice
- Microdialysis Assessment of Microfibrous Collagen Containing Sodium Alginate for Local Delivery of Amikacin
- Rectal Absorption of a 5-HT_3 Receptor Antagonist, Ondansetron, from a Suppository Containing a Tablet in Rabbits
- Magnetic Targeting of Thermosensitive Magnetoliposomes to Mouse Livers: An In Situ On-line Perfusion System.
- THE CHANGE OF P-AMINOHIPPURIC ACID DISPOSITION KINETICS ACCOMPANIED BY GROWTH IN MICE
- EFFECT OF HYPOTHERMIA AND ETHER ANESTHESIA ON THE DISPOSITIONS OF CREATININE AND UREA IN MICE
- DIFFERENCE IN FENITROTHION-INHIBITED RAT PLASMA CHOLINESTERASE ACTIVITIES DETERMINED BY ΔpH-METHOD AND DTNB-METHOD, DUE TO SPONTANEOUS REACTIVATION
- Effect of Freeze-Thawing and Polyethylene Glycol (PEG) Lipid on Fusion and Fission of Phospholipid Vesicles
- EFFECT OF ASYMMETRIC DISTRIBUTION OF INNER MEMBRANE SURFACTANT ON ION PERMEATION THROUGH LIPOSOMAL MEMBRANE
- Size Growth Factor in the Process of Vesicle Formation form Phospholipid-Detergent Mixed Mecelles
- Hyperfine Splitting of 2, 2, 6, 6-Tetramethylpiperidine-N-oxyl in Octyl β-D-Glucoside-Containing Large Unilamellar Vesicle Suspensions
- Size Control of Mixed Egg Yolk Phosphatidylcholine (EggPC)/Oleate Vesicles
- GASTRO-INTESTINAL ABSORPTION OF HEPARIN
- HEPARIN-INDUCED LEUKOCYTE LYSIS IN VITRO
- SPONTANEOUS REACTIVATION OF MOUSE PLASMA CHOLINESTERASE AFTER INHIBITION BY VARIOUS ORGANOPHOSPHORUS COMPOUNDS
- CHEMICAL REACTIVATIONS OF INACTIVATED ACETYLCHOLINESTERASE AFTER 2-PAM THERAPY IN FENITROTHION-POISONED RAT AND RABBIT
- TOPOGRAPHICAL ANALYSIS FOR COATED VESICLE H^+-ATPase DERIVED FROM CALF BRAIN
- POSSIBLE ANTIDOTES IN SEVERE INTOXICATION WITH FENITROTHION IN RATS
- BASIC STUDY ON HEPATIC ARTERY CHEMOEMBOLIZATION USING TEMPERATURE-SENSITIVE LIPOSOME
- SPONTANEOUS REACTIVATION OF FENITRO-OXON-INHIBITED PLASMA CHOLINESTERASE IN VARIOUS MAMMALS
- Reconsideration of Drug Release from Temperature-Sensitive Liposomes
- Physicochemical Properties of PEG-Grafted Liposomes
- Membrane Fluidity of Egg Yolk Phosphatidylcholine/Detergent Mixed Aggregates Studied by Spin Label Method
- New Vesicle Formation upon Oleate Addition to Preformed Vesicles
- Pharmaceutical Studies on the Medicinal Prescription Used in Traditional Sino-Japanese Medicine : Changes of the Components in Keishibukuryo-gan Prepared in the Hospital Pharmacy
- 13C-NMR study of aerosol OT in chloroform.
- The behavior of aerosol OT in organic solvents.
- Characteristics of the Membrane Permeability of Temperature-Sensitive Liposome.