Pharmaceutical Studies on the Medicinal Prescription Used in Traditional Sino-Japanese Medicine : Changes of the Components in Keishibukuryo-gan Prepared in the Hospital Pharmacy

概要

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The time courses of the amounts of the reference substances in the pills called Keishibukuryogan (Gui-Zni-Fu-Ling-Wan) were determined. The pills were prepared from powdered crude drugs and honey in our hospital according to the specifications of the classical Chinese medicine, and were kept at 4℃ or room temperature (ca. 25℃). Six compounds, namely cinnamic aldehyde, paeonol, paeoniflorin, amygdalin, prunasin and benzaldehyde, were used as reference substances. After 2 weeks, 1 month, 3 months or 6 months, quantitative analysis of their contents in the pills was carried out by high performance liquid chromatography. The amounts of cinnamic aldehyde, paeonol and paeoniflorin decreased after the preparation. When the pills were kept at room temperature, their amygdalin content decreased rapidly, while their benzaldehyde content increased. However, when the pills were prepared freshly from the powder which had been kept at 4℃ for 6 months, the amounts of the reference substances in those pills differed only slightly from those of the pills just prepared at 0 time. As for the prunasin content, the changes were negligible or none.
日本生薬学会の論文
1988-03-20