DIFFERENCE IN FENITROTHION-INHIBITED RAT PLASMA CHOLINESTERASE ACTIVITIES DETERMINED BY ΔpH-METHOD AND DTNB-METHOD, DUE TO SPONTANEOUS REACTIVATION
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概要
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Rat cholinesterase (ChE) activities were measured by DTNB-method after an oral administration of fenitrothion, and the following facts were observed. The inhibited plasma ChE (pseudo ChE) obtained within several hours after the administration was spontaneously reactivated at 10℃ or over, whereas no reactivation was observed at 1℃. Neither red blood cell nor brain ChE (true ChE) was spontaneously reactivated. In vitro, the spontaneous reactivation was also observed in rat plasma ChE inhibited by oxon-type of fenitrothion. In case the activity of plasma ChE obtained 30 min after administration was determined by ΔpH-method, the activity was higher than the actual value, because of the spontaneous reactivation taking place during an incubation for 1 h at 37℃. It is suggested from these results that an utilization of ΔpH-method is unsuitable for the measurement of the activity of inhibited ChE which is spontaneously reactivated.
- 公益社団法人日本薬学会の論文
著者
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HORIKOSHI Isamu
Department of Hospital Pharmacy Toyama Medical and Pharmaceutical University
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Matsubara Toshiyuki
Department Of Biotechnology Tottori University
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Matsubara Toshiyuki
Department Of Hospital Pharmacy Toyama Medical And Pharmaceutical University
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