HEPARIN-INDUCED LEUKOCYTE LYSIS IN VITRO
スポンサーリンク
概要
- 論文の詳細を見る
An investigation on the effect of heparin on leukocytes in vitro was conducted. We have demonstrated that heparin and other mucopolysaccharides destroyed leukocytes as judged by macromolecule leakage. The cytotoxicity of heparin was suppressed by protamine. A medium which mimics intracellular ionic conditions was found to suppress the cytotoxicity of heparin. Macromolecule leakage induced by heparin is thought to be facilitated by passive ion flux. Mepacrine, a phospholipase inhibitor, suppressed the heparin-induced macromolecule leakage from leukocytes. Thus, the activation of phospholipase appears to be involved in the cytotoxicity of heparin. These results suggest that activation of phospholipase and passive movement of ions may be important steps for the heparin-induced leukocyte lysis in vitro.
- 公益社団法人日本薬学会の論文
著者
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HORIKOSHI Isamu
Department of Hospital Pharmacy Toyama Medical and Pharmaceutical University
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Ueno Masaharu
Faculty Of Pharmaceutical Sciences Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Adachi Isao
Department Of Hospital Pharmacy Toyama Medical And Pharmaceutical University
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Ueno Masaharu
Department Of Chemistry School Of Science And Graduate School Of Pharmaceutical Sciences The Univers
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IWAKI HARUMI
Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical University
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ADACHI HIROKAZU
Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical University
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Adachi Hirokazu
Department Of Hospital Pharmacy Toyama Medical And Pharmaceutical University
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Iwaki Harumi
Department Of Hospital Pharmacy Toyama Medical And Pharmaceutical University
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ADACHI Isao
Department of Applied Mathematics Osaka University
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