THE CHANGE OF P-AMINOHIPPURIC ACID DISPOSITION KINETICS ACCOMPANIED BY GROWTH IN MICE

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The change of disposition kinetics for p-aminohippuric acid (PAH) was studied following intravenous administration of p-[glycyl-1-^<14>C] aminohippuric acid to 1-day-old, 1-week-old, 3-week-old and 8-week-old mice. The expiratory excretion of ^<14>CO_2 in 24 h following the administration was almost negligible in 1-day-old and 1-week-old mice in contrast to 3-week-old (6.8±1.8%) and 8-week-old (8.8±1.9%) mice. The ability to metabolize PAH may not be developed in these infant mice.The elimination of blood radioactivity following the administration was considerably delayed in 1-day-old and 1-week-old mice, especially in 1-day-old mice, suggesting that the renal trubular secretory function for PAH might not have been developed in the infant mice. Whole-body autoradiographic data showed that the transfer of PAH form blood to muscle was enhanced in 1-day-old and 1-week-old mice, especially in 1-day-old mice, compared to 3-week-old and 8-week-old mice. The enhanced muscular cell membrane permeability to PAH in 1-day-old and 1-week-old mice was considered to be the most plausible explanation for this result.
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