AGE-DEPENDENT CHANGES IN WARFARIN TISSUE DISTRIBUTION
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概要
- 論文の詳細を見る
Whole blood levels, serum protein binding and tissue concentration following intravenous administration of warfarin were investigated in 1-d-old, 1-, 3- and 8-week-old rats to determine the drug disposition in the growth process. It was shown that the clearance of warfarin in 1-d-old or 1-week-old rats was considerably lower than that in 3- or 8-week-old rats. The decrease in clearance in infant and young rats was considered to be caused by the immaturity of the physiological function of the liver to remove exogenous compounds. The distribution volume in 1-d-old or 1-week-old rats was larger than that in 3- or 8-old rats. The percentages of serum free warfarin in 1-d-old and 1-week-old rats were about twice those in 3- and 8-week-old rats. The increased distribution volume in infant rats was considered to be caused by a lower serum protein binding in these rats.
- 公益社団法人日本薬学会の論文
著者
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Kato Yoshihisa
School Of Pharmaceutical Science University Of Shizuoka
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HORIKOSHI Isamu
Department of Hospital Pharmacy Toyama Medical and Pharmaceutical University
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Sakaguchi Kazuo
Department Of Hospital Pharmacy Toyama Medical And Pharmaceutical University
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Ueno Masaharu
Department Of Hospital Pharmacy Toyama Medical And Pharmaceutical University
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HIRATE Junji
Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical University
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Hirate J
Department Of Hospital Pharmacy Toyama Medical And Pharmaceutical University
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Hirate Junji
Department Of Hospital Pharmacy Toyama Medical And Pharmaceutical University
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Kato Y
Yoshitomi Pharmaceutical Industries Ltd. Fukuoka Jpn
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Kato Yoshiteru
Formulation Research Lab. Kawashima Industrial Park Eisai
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Horikoshi I
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Ueno Masaharu
Department Of Chemistry School Of Science And Graduate School Of Pharmaceutical Sciences The Univers
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