Nasal Absorption of Digoxin in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The nasal administration of digoxin was studied in rats and compared to intravenous, intraduodenal and rectal administration of the drug. The results indicated that the plasma level of digoxin after nasal administration was comparable to the level after intravenous injection. Administration by the intraduodenal and rectal routes resulted in considerably lower plasma levels. These data reveal that digoxin absorption across the nasal membranes is a reasonable approach. In the in situ nasal and intestinal perfusion experiments, digoxin disappeared from the perfusate following the apparent first-order kinetics. The nasal and intestinal absorption rate of digoxin was reduced by an increase in the perfusion volume. The plot of absorption rate constant against 1/volume resulted in a straight line, suggesting that digoxin is absorbed from nasal mucosa by a passive diffusion process.
- 公益社団法人日本薬学会の論文
著者
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SATO Masaki
Department of Internal Medicine 2, Fukushima Medical University School of Medicine
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Kato Yoshihisa
Department of Internal Medicine, Fujita-Gakuen University School of Medicine
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Kato Yoshihisa
Department Of Internal Medicine School Of Medicine Fujita Health Univ.
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Kato Yoshihisa
School Of Pharmaceutical Sciences University Of Shizuoka
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YAMADA Shizuo
Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) Program, S
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Sato M
School Of Pharmaceutical Sciences University Of Shizuoka:(present Address)marusa Corporation
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Kato Yoshihisa
School Of Pharmaceutical Science University Of Shizuoka
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Kato Y
Univ. Shizuoka Shizuoka Jpn
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KIMURA Ryohei
Department of Biopharmacy, School of Pharmaceutical Sciences, University of Shizuoka
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Yamada Shizuo
Department Of Pharmacokinetics And Pharmacodynamics School Of Pharmaceutical Sciences University Of
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Yamada Shizuo
Department Of Biophamacy School Of Pharmaceutical Sciences University Of Shizuoka
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佐藤 真友美
Univ. Shizuoka Shizuoka Jpn
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YAGI Nobuyuki
Department of Biopharmacy, School of Pharmaceutical Sciences, University of Shizuoka
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Kimura Ryohei
School Of Pharmaceutical Sciences University Of Shizuoka
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Kimura R
Graduate School Of Engineering Tohoku University
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Kimura Ryohei
Department Of Biophamacy School Of Pharmaceutical Sciences University Of Shizuoka
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Kato Yoshiteru
Formulation Research Lab. Kawashima Industrial Park Eisai
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Yamada S
School Of Pharmaceutical Sciences University Of Shizuoka
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SATO Masaki
the Faculty of Science and Engineering, Chuo University
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Sato Masaki
Department Of Internal Medicine 2 Fukushima Medical University School Of Medicine
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Sato Masaki
The Faculty Of Science And Engineering Chuo University
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Kato Yoshihisa
静岡県立大学 薬
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Yagi Nobuyuki
Department Of Biopharmacy School Of Pharmaceutical Sciences University Of Shizuoka
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Sato Masaki
Department Of Aeronautics And Space Engineering Tohoku University
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KATO YOSHIHISA
School of Pharmaceutical Sciences, University of Shizuoka
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