The 5-HT_2 Receptor Antagonist Reduces Immobility of Mice Treated with the Atypical Antidepressant Mianserin in the Forced Swimming Test

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概要

• 論文の詳細を見る

• Effects of co-administration with the 5-HT_2 receptor antagonist LY 53857 and the antidepressant mianserin on immobility time in the forced swimming test were investigated in mice. Mianserin did not affect the immobility time at ranges from 1-10 mg/kg, although it elicited anti-immobility effects at 20 mg/kg. Co-administration of the 5-HT2 receptor antagonist LV 53857 and a subactive dose of mianserin induced apparent anti-immobility effects. Since mianserin facilitates noradrenaline (NA) release from nerve terminals via inhibition of α_2 receptors, the blockade of the 5-HT_2 receptor may increase the antidepressant effect of drugs modifying NA levels in the synaptic cleft.

• 社団法人日本薬学会の論文
• 2002-11-01

著者

• YAMADA Jun

  Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo

• YAMADA Shizuo

  Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) Program, S

• Yamada Shizuo

  Departments Of Pharmacokinetics And Pharmacodynamics Pharmacognosy And Global Center Of Excellence (

• Yamada S

  School Of Pharmaceutical Sciences And Coe21 University Of Shizuoka

• Yamada Shizuo

  Department Of Pharmacokinetics And Pharmacodynamics And Global Center Of Excellence (coe) And Clinic

• Yamada S

  Department Of Biopharmacy University Of Shizuoka School Of Pharmaceutical Sciences

• SUGIMOTO Yumi

  Department of Pharmacology, Kobe Pharmaceutical University

• Sugimoto Yumi

  Department Of Pharmacology Kobe Pharmaceutical University

• Yamada Shizuo

  Department Of Biophamacy School Of Pharmaceutical Sciences University Of Shizuoka

• Sugimoto Yumi

  Department Of Pharmacology Kobe Women's College Of Pharmacy.

• Yamada Jun

  Department Of Pharmacology Kobe Pharmaceutical University

• Yamada Jun

  Department Of Electrical And Electronics Engineering Aichi Institute Of Technology

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