The involvement of serotonergic and dopaminergic systems in hypothermia induced in mice by intracerebroventricular injection of serotonin.
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概要
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The hypothermia elicited in mice by intracerebroventricular injection (i.c.v.) of serotonin (5-HT) was studied. The 5-HT-induced hypothermia was attenuated by methysergide and pindolol, although ketanserin and p-chlorophenylalanine were without effect. These results suggest that 5-HT-induced hypothermia is produced by the direct activation of the 5-HT<SUB>1</SUB> receptor. In addition, haloperidol, pimozide and α-MT inhibited 5-HT-induced hypothermia, which indicates that the dopaminergic systems are also involved in 5-HT-induced hypothermia in mice.
- 公益社団法人 日本薬理学会の論文
著者
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Sugimoto Yumi
Department Of Pharmacology Kobe Pharmaceutical University
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Horisaka Kazuyoshi
Department Of Pharmacology Kobe Pharmaceutical University
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Yamada Jun
Department Of Electrical And Electronics Engineering Aichi Institute Of Technology
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WAKITA Hiromi
Department of Pharmacology, Kobe Women's College of Pharmacy
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