EFFECTS OF ω-AMINOSULFONIC ACIDS ON LIPID METABOLISM IN DIETARY HYPERLIPIDEMIC RATS
スポンサーリンク
概要
- 論文の詳細を見る
The effects of 2-aminoethanesulfonic acid (taurine) and its structural analogs, 3-aminopropanesulfonic acid (homotaurine) and 4-aminobutanesulfonic acid (ABSA), on lipid metablism were investigated in rats with dietary hyperlipidemia. The serum choles terol levels increased approximately five-fold in rats fed a diet containing 0.5% cholesterol and 1% cholic acid for 10 d. ω-Aminosulfonic acids dissolved in water were orally administered for 10 d concurrently with the 0.5% cholesterol diet. Taurine suppressed elevation in serum cholesterol levels by 46.9 and 63.9% at doses of 250 and 500 mg/kg, respectively. Serum triglycerides levels, however, were not significantly altered by taurine. Both homotaurine and ABSA, 500 mg/kg each, inhibited the elevation in serum cholesterol levels to an extent, namely, 32.0 and 22.3% lower than that of the controls, respectively. Treatment with homotaurine in doses of 250 and 500 mg/kg significantly increased serum triglycerides levels by 37.6 and 35.9%, respectively, and ABSA (500 mg/kg) also revealed a tendency to raisethese levels. All the sulfonic acids (500 mg/kg each) reduced cholesterol levels in the liver similarly, while changes in triglycerides levels in the liver were insignificant. Both taurine and homotaurine (500 mg/kg each) inhibited intestinal absorption of cholesterol. The inhibitory effect of homotaurine was as great as 31.5% and greater than that of taurine. No influence of taurine (500 mg/kg) was observed in lipoprotein lipase activity in the epididymal fat tissue, but the activity did appear to be inhibited by homotaurine(500 mg/kg).
- 公益社団法人日本薬学会の論文
著者
-
YAMADA Jun
Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo
-
MASUDA Midori
Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University
-
Masuda Midori
Department Of Pharmacology Kobe Women's College Of Pharmacy
-
HORISAKA Kazuyoshi
Department of Pharmacology, Kobe Pharmaceutical University
-
Horisaka Kazuyoshi
Department Of Pharmacology Kobe Pharmaceutical University
-
TANAKA MITSUYO
Department of Pharmacology, Kobe Women's College of Pharmacy
-
Tanaka Mitsuyo
Department Of Pharmacology Kobe Women's College Of Pharmacy
-
Yamada Jun
Department Of Pharmacology Kobe Pharmaceutical University
-
Yamada Jun
Department Of Electrical And Electronics Engineering Aichi Institute Of Technology
-
Yamada Jun
Department Of Pharmacology Kobe Women's College Of Pharmacy
関連論文
- Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer
- Mechanism of Hypertension Induced by Chronic Inhibition of Nitric Oxide in Rats
- The 5-HT_2 Receptor Antagonist Reduces Immobility of Mice Treated with the Atypical Antidepressant Mianserin in the Forced Swimming Test
- Increases in Plasma Ouabainlike Immunoreactivity during Surgical Extirpation of Pheochromocytoma
- Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation
- Early gastric cancer with Krukenberg tumor and review of cases of intramucosal gastric cancers with Krukenberg tumor
- The Tricyclic Antidepressant Clomipramine Increases Plasma Glucose Levels of Mice
- Involvement of Serotonin in Zimelidine-Induced Hyperglycemia in Mice
- Effects of Peripheral Administration of 5-Hydroxytryptamine (5-HT) on 2-Deoxy-D-glucose-Induced Hyperphagia in Rats(Pharmacology)
- The 5-HT^ Receptor Agonist m-Chlorophenylpiperazine(mCPP)Inhibits 2-Deoxy-D-glucose(2-DG)-Induced Hyperphagia in Rats
- Effects of a Nitric Oxide Synthase Inhibitor on Hypophagia Induced by the Peripheral 5-HT Receptor Agonists, α-Methyl-5-hydroxytryptamine and 5-Carboxamidotryptamine in Rats
- Inhibitory Effects of a Nitric Oxide Synthase Inhibitor, N^G-Nitro-L-arginine Methyl Ester (L-NAME), on 2-Deoxy-D-glucose-Induced Hyperglycemia in Rats
- The Effects of Peripheral Serotonin_2 (5-HT_2) and Serotonin_3 (5-HT_3) Receptor Agonists on Blood Glucose Levels in Rats
- Involvement of Leptin in Hypophagia Induced by the Serotonin Precursor 5-Hydroxytryptophan (5-HTP) in Mice(Pharmacology)
- Inhibitory Effects of the 5-HT_ Receptor Agonist Buspirone on Stress-Induced Hyperglycemia in Mice : Involvement of Insulin and a Buspirone Metabolite, 1-(2-Pyrimidinyl) piperazine (1-PP)(Pharmacology)
- Effects of the Serotonergic Anxiolytic Buspirone on Plasma Glucose and Glucose-Induced Hyperglycemia in Mice
- Effects of Insulin and Adrenalectomy on Elevation of Serum Leptin Levels Induced by 5-Hydroxytryptophan in Mice(Pharmacology)
- Leptin Inhibits Food Intake without Affecting Brain NOx Levels in Food-Deprived Mice(Pharmacology)
- SIMULTANEOUS DETERMINATION OF TRYPTOPHAN AND ITS METABOLITES IN BIOLOGICAL SAMPLES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH FLUOROMETRIC DETECTION
- EFFECTS OF ω-AMINOSULFONIC ACIDS ON LIPID METABOLISM IN DIETARY HYPERLIPIDEMIC RATS
- EFFECT OF TRYPTAMINE ON THE BEHAVIOR OF MICE
- ELEVATION OF SERUM INDOLEACETIC ACID LEVELS IN RATS WITH EXPERIMENTAL LIVER FAILURE
- INDOLEACETIC ACID-INDUCED HYPOTHERMIA AND CHANGES IN SEROTONIN METABOLISM IN MICE
- ω-AMINOSULFONIC ACIDS AS DEPRESSANT OR EXCITANT COMPOUNDS : THEIR EFFECT ON THE BEHAVIOR AND ELECTROENCEPHALOGRAM OF YOUNG CHICKENS
- EFFECT OF TAURINE AND HOMOTAURINE ON BILE ACID METABOLISM IN DIETARY HYPERLIPIDEMIC RATS
- INDUCTION AND SUPPRESSION OF AMINOSULFONIC ACID SPIKES IN WULST EEG OF ADULT CHICKENS
- The 5-HT_1A Receptor Agonist 8-Hydroxy-2-di-n-(propylamino)tetralin(8-OH-DPAT)Induces Hyperglucagonemia in Rats
- Study on Physical Properties of Plasma Generated by YAG Laser in Liquid
- Intraperitoneal administration of paclitaxel solubilized with poly(2-methacryloxyethyl phosphorylcholine-co n-butyl methacrylate) for peritoneal dissemination of gastric cancer
- Effect of the 5-HT_ Receptor Agonist 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on Plasma Glucose and Glucagon Levels of Rats
- Al, Cu and W Oxide Fine Particles Produced by Discharge Explosions
- The Printing Mask for Electron Diffraction Photographs
- Effects of the 5-HT_2 Receptor Antagonist, Ritanserin on Hyperthermia and Depletion of 5-HT in Frontal Cortex Induced by a 5-HT Releasing Drug, p-Chloroamphetamine(PCA)in Mice
- Dissecting Aneurysm of the Middle Cerebral Artery Manifesting as Subarachnoid Hemorrhage and Hemorrhagic Infarctions : Case Report
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. VI. EFFECTS OF L-ASCORBATE 2-SULFATE ON LIPID METABOLISM IN GUINEA PIGS
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. V. ON THE HYPOLIPIDEMIC AND ANTIATHEROSCLEROTIC EFFECTS OF L-ASCORBATE 2-SULFATE IN RABBITS
- HYPOTHERMIC EFFECT OF ω-AMINOSULFONIC ACIDS
- EFFECT OF INTRAVENTRICULAR INJECTIONS OF ω-AMINOSULFONIC ACIDS ON THE CENTRAL NERVOUS SYSTEM OF CONSCIOUS MICE
- Impedance of a Partially Ionized Cecium Plasma
- Production and Physical Properties of Cesium Plasma by Resonance Absorption
- Contribution of Dissociative Recombination to a Cesium Plasma Produced by Resonance Absorption
- Physical Properties of Dense Plasma Produced by XeCl Excimer Laser in High-Pressure Argon Gases
- On the Surface Character of Chert Clasta
- Spectroscopic Measurement of High-Pressure Argon Plasma Produced by Excimer Laser
- Effects of serotonin on blood glucose and insulin levels of glucose- and streptozotocin-treated mice.
- Effects of taurine on neutrophil function in hyperlipidemic rats.
- A Novel Method Detecting Hypercoagulability in Small Experimental Animals:Comparison between Spontaneously Hypertensive and Normotensive Rats
- The Effects of the Serotonin1A Receptor Agonist Buspirone on the Blood Glucose and Pancreatic Hormones in Rats.
- The involvement of serotonergic and dopaminergic systems in hypothermia induced in mice by intracerebroventricular injection of serotonin.