The Effects of the Serotonin1A Receptor Agonist Buspirone on the Blood Glucose and Pancreatic Hormones in Rats.
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概要
- 論文の詳細を見る
The effects of the serotonin<SUB>1A</SUB> (5-HT<SUB>1A</SUB>) receptor agonist buspirone on the plasma glucose and pancreatic hormones insulin and glucagon were investigated in rats. Buspirone elicited significant hyperglycemia and hyperglucagonemia, although it did not affect the insulin levels. Adrenodemedullation inhibited both the increase in blood glucose and glucagon levels. These results indicate that buspirone-induced hyperglycemia and hyperglucagonemia are mediated by adrenaline release from the adrenal gland.
- 公益社団法人 日本薬理学会の論文
著者
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Sugimoto Yumi
Department Of Pharmacology Kobe Pharmaceutical University
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Horisaka Kazuyoshi
Department Of Pharmacology Kobe Pharmaceutical University
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Watanabe Yoshiko
Department Of Cardiology Nishitokyo Central General Hospital
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Yamada Jun
Department Of Electrical And Electronics Engineering Aichi Institute Of Technology
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Watanabe Yoshiko
Department of Pharmacology, Kobe Women''s College of Pharmacy
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