Effects of the 5-HT_2 Receptor Antagonist, Ritanserin on Hyperthermia and Depletion of 5-HT in Frontal Cortex Induced by a 5-HT Releasing Drug, p-Chloroamphetamine(PCA)in Mice
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概要
- 論文の詳細を見る
Effects of the 5-HT_2 receptor antagonist, ritanserin on hyperthermia and depletion of 5-HT induced by the 5-HT-releasing drug, p-chloroamphetamine(PCA)were investigated. Ritanserin significantly suppressed PCA-induced hyperthermia in mice. PCA elicited decreases in 5-HT levels in the mouse frontal cortex. 5-HT reduction elicited by PCA was also Attenuated by pretreatment with ritanserin. Since hyperthermia facilitates neurotoxicity induced by amphetamine analogue, ritanserin may inhibit PCA-induced 5-HT neurotoxicity by inhibiting hyperthermia.
- 公益社団法人日本薬学会の論文
- 2001-10-01
著者
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ohkura Minako
Department of Internal Medicine, Asahikawa City Hospital
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YAMADA Jun
Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo
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Ohkura M
Department Of Pharmacology Kobe Pharmaceutical University
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SUGIMOTO Yumi
Department of Pharmacology, Kobe Pharmaceutical University
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Sugimoto Yumi
Department Of Pharmacology Kobe Pharmaceutical University
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lNOUE Kiyo
Department of Pharmacology, Kobe Pharmaceutical University
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Lnoue Kiyo
Department Of Pharmacology Kobe Pharmaceutical University
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Yamada Jun
Department Of Pharmacology Kobe Pharmaceutical University
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Yamada Jun
Department Of Electrical And Electronics Engineering Aichi Institute Of Technology
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