Effect of the 5-HT_<2A> Receptor Agonist 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on Plasma Glucose and Glucagon Levels of Rats

スポンサーリンク

概要

• 論文の詳細を見る

• Effects of the 5-hydroxytryptamine (5-HT)_<2A> receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane (DOI) on plasma glucagon levels studied in rats. Systemic injection of DOI induces significant increases in plasma glucagon levels. Hyperglucagonemia induced by DOI was dose-dependently prevented by the 5-HT_<2A> receptor antagonist ketanserin. Adrenodemedullation abolished hyperglucagonemia elicited by DOI. Previous report demonstrated that the peripheral 5-HT_<2A> receptor agonist induces hyperglycemia in rats but does not increase plasma glucagon levels at doses inducing hyperglycemia. Therefore, our findings suggest that DOI-induced glucagon release was elicited by stimulation of the central 5-HT_<2A> receptor, which in turn increasing adrenaline release.

• 公益社団法人日本薬学会の論文
• 2000-12-01

著者

• YAMADA Jun

  Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo

• SUGIMOTO Yumi

  Department of Pharmacology, Kobe Pharmaceutical University

• Sugimoto Yumi

  Department Of Pharmacology Kobe Pharmaceutical University

• Sugimoto Yumi

  Department Of Pharmacology Kobe Women's College Of Pharmacy.

• Yamada Jun

  Department Of Electrical And Electronics Engineering Aichi Institute Of Technology

関連論文

• Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer
• Bilateral Optic Disc Macroaneurysm Associated with Acquired Vascular Loop
• Antiallergic Effect of Flavonoid Glycosides Obtained from Mentha pipertita L.
• The 5-HT_2 Receptor Antagonist Reduces Immobility of Mice Treated with the Atypical Antidepressant Mianserin in the Forced Swimming Test
• Fluvoxamine の強制水泳試験における不動時間短縮作用と serotonin 受容体との関連について
• Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation
• Fluvoxamine の強制水泳試験における作用の性差に関する検討
• 強制水泳試験における dopamine 再取り込み阻害薬の不動時間短縮作用とセロトニン_2受容体サブタイプとの関連
• Marble burying behavior に対する leptin の影響
• Dopamine 再取り込み阻害薬の強制水泳試験における影響
• 選択的セロトニン再取り込み阻害薬の生体内動態と薬効
• 選択的セロトニン再取り込み阻害薬 fluoxetine の強制水泳試験における影響と5-HT_4受容体の関与について
• 7系統マウスにおける Marble burying behavior の系統差について
• Early gastric cancer with Krukenberg tumor and review of cases of intramucosal gastric cancers with Krukenberg tumor
• The Tricyclic Antidepressant Clomipramine Increases Plasma Glucose Levels of Mice
• Involvement of Serotonin in Zimelidine-Induced Hyperglycemia in Mice
• Effects of Peripheral Administration of 5-Hydroxytryptamine (5-HT) on 2-Deoxy-D-glucose-Induced Hyperphagia in Rats(Pharmacology)
• The 5-HT^ Receptor Agonist m-Chlorophenylpiperazine(mCPP)Inhibits 2-Deoxy-D-glucose(2-DG)-Induced Hyperphagia in Rats
• Effects of a Nitric Oxide Synthase Inhibitor on Hypophagia Induced by the Peripheral 5-HT Receptor Agonists, α-Methyl-5-hydroxytryptamine and 5-Carboxamidotryptamine in Rats
• Inhibitory Effects of a Nitric Oxide Synthase Inhibitor, N^G-Nitro-L-arginine Methyl Ester (L-NAME), on 2-Deoxy-D-glucose-Induced Hyperglycemia in Rats
• The Effects of Peripheral Serotonin_2 (5-HT_2) and Serotonin_3 (5-HT_3) Receptor Agonists on Blood Glucose Levels in Rats
• Involvement of Leptin in Hypophagia Induced by the Serotonin Precursor 5-Hydroxytryptophan (5-HTP) in Mice(Pharmacology)
• Inhibitory Effects of the 5-HT_ Receptor Agonist Buspirone on Stress-Induced Hyperglycemia in Mice : Involvement of Insulin and a Buspirone Metabolite, 1-(2-Pyrimidinyl) piperazine (1-PP)(Pharmacology)
• Effects of the Serotonergic Anxiolytic Buspirone on Plasma Glucose and Glucose-Induced Hyperglycemia in Mice
• Effects of Insulin and Adrenalectomy on Elevation of Serum Leptin Levels Induced by 5-Hydroxytryptophan in Mice(Pharmacology)
• Leptin Inhibits Food Intake without Affecting Brain NOx Levels in Food-Deprived Mice(Pharmacology)
• Effects of the Serotonin and Noradrenaline Reuptake Inhibitor (SNRI) Milnacipran on Marble Burying Behavior in Mice(Pharmacology)
• SIMULTANEOUS DETERMINATION OF TRYPTOPHAN AND ITS METABOLITES IN BIOLOGICAL SAMPLES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH FLUOROMETRIC DETECTION
• EFFECTS OF ω-AMINOSULFONIC ACIDS ON LIPID METABOLISM IN DIETARY HYPERLIPIDEMIC RATS
• EFFECT OF TRYPTAMINE ON THE BEHAVIOR OF MICE
• ELEVATION OF SERUM INDOLEACETIC ACID LEVELS IN RATS WITH EXPERIMENTAL LIVER FAILURE
• INDOLEACETIC ACID-INDUCED HYPOTHERMIA AND CHANGES IN SEROTONIN METABOLISM IN MICE
• The 5-HT_1A Receptor Agonist 8-Hydroxy-2-di-n-(propylamino)tetralin(8-OH-DPAT)Induces Hyperglucagonemia in Rats
• Effect of Docosahexaenoic Acid-Fortified Chlorella vulgaris Strain CK22 on the Radial Maze Performance in Aged Mice
• Study on Physical Properties of Plasma Generated by YAG Laser in Liquid
• Intraperitoneal administration of paclitaxel solubilized with poly(2-methacryloxyethyl phosphorylcholine-co n-butyl methacrylate) for peritoneal dissemination of gastric cancer
• Effect of the 5-HT_ Receptor Agonist 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on Plasma Glucose and Glucagon Levels of Rats
• Al, Cu and W Oxide Fine Particles Produced by Discharge Explosions
• The Printing Mask for Electron Diffraction Photographs
• Effects of the 5-HT_2 Receptor Antagonist, Ritanserin on Hyperthermia and Depletion of 5-HT in Frontal Cortex Induced by a 5-HT Releasing Drug, p-Chloroamphetamine(PCA)in Mice
• Dissecting Aneurysm of the Middle Cerebral Artery Manifesting as Subarachnoid Hemorrhage and Hemorrhagic Infarctions : Case Report
• FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. VI. EFFECTS OF L-ASCORBATE 2-SULFATE ON LIPID METABOLISM IN GUINEA PIGS
• FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. V. ON THE HYPOLIPIDEMIC AND ANTIATHEROSCLEROTIC EFFECTS OF L-ASCORBATE 2-SULFATE IN RABBITS
• HYPOTHERMIC EFFECT OF ω-AMINOSULFONIC ACIDS
• Impedance of a Partially Ionized Cecium Plasma
• Production and Physical Properties of Cesium Plasma by Resonance Absorption
• Contribution of Dissociative Recombination to a Cesium Plasma Produced by Resonance Absorption
• Physical Properties of Dense Plasma Produced by XeCl Excimer Laser in High-Pressure Argon Gases
• On the Surface Character of Chert Clasta
• Spectroscopic Measurement of High-Pressure Argon Plasma Produced by Excimer Laser
• Effects of serotonin on blood glucose and insulin levels of glucose- and streptozotocin-treated mice.
• The Effects of the Serotonin1A Receptor Agonist Buspirone on the Blood Glucose and Pancreatic Hormones in Rats.
• The involvement of serotonergic and dopaminergic systems in hypothermia induced in mice by intracerebroventricular injection of serotonin.
• P-65 蓮子心のアルカロイドおよび誘導体の合成と薬理活性(ポスター発表の部)

もっと見る 閉じる

スポンサーリンク