Leptin Inhibits Food Intake without Affecting Brain NOx Levels in Food-Deprived Mice(Pharmacology)
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概要
- 論文の詳細を見る
Effects of leptin on food intake and nitric oxide (NO) metabolites (nitrite and nitrate, NOx) levels of brain were investigated in mice. Leptin dose-dependently decreased milk intake in food-deprived mice. Administration of leptin at a dose of 1 mg/kg, which induces an apparent hypophagia, did not affect NOx levels in the hypothalamus and frontal cortex. These results suggest that leptin reduces food intake in food-deprived mice without altering NO production in the hypothalamus, which plays an important role in regulation of feeding.
- 公益社団法人日本薬学会の論文
- 2003-01-01
著者
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YAMADA Jun
Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo
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杉本 由美
神戸薬科大学、薬理学研究室
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HIROSE Hiroshi
Department of Internal Medicine, School of Medicine, Keio University
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Sugimoto Yoshihiko
Department Of Ophthalmology Faculty Of Medical Science University Of Fukui
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SUGIMOTO Yumi
Department of Pharmacology, Kobe Pharmaceutical University
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Sugimoto Y
Dep. Of Pharmacology Kobe Pharmaceutical Univ.
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Sugimoto Yumi
Department Of Pharmacology Kobe Pharmaceutical University
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Sugimoto Yumi
Laboratory Of Pharmacology Department Of Clinical Pharmacy Yokohama College Of Pharmacy:department O
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Sugimoto Yoko
Department Of Ophthalmology Faculty Of Medical Science University Of Fukui
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杉本 由美
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
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Sugimoto Yumi
Dep. Of Pharmacology Kobe Pharmaceutical Univ.
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Sugimoto Yumi
Department Of Pharmacology Kobe Women's College Of Pharmacy.
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YAGURA Tatsuo
Department of Bioscience, Faculty of Science and Technology, Kwansei-Gakuin University
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Yagura Tatsuo
Department Of Biology Faculty Of Science Hokkaido University:(present)department Of Immunology And V
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Yagura Tatsuo
Department Of Bioscience Faculty Of Science And Technology Kwansei-gakuin University
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Hirose H
Department Of Pharmacology Kobe Pharmaceutical University
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Sugimoto Y
Department Of Ophthalmology Faculty Of Medical Science University Of Fukui
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Yamada Jun
Department Of Pharmacology Kobe Pharmaceutical University
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Yamada Jun
Department Of Electrical And Electronics Engineering Aichi Institute Of Technology
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Hirose Hiroshi
Department Of Internal Medicine Keio University School Of Medicine
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