Serotonin_2 (5-HT_2) Receptor Agonist 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI) Inhibits Chlorpromazine-and Haloperidol-Induced Hypothermia in Mice
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概要
- 論文の詳細を見る
Chlorpromazine-and haloperidol-induced hypothermia were examined in mice. The α_1 receptor agonist phenylephrine partially antagonized the hypothermia, while the dopamine D_2 receptor agonist apomorphine did not inhibit it. The central serotonin_2 (5-HT_2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) strongly inhibited the chlorpromazine-and haloperidol-induced hypothermia. Both drugs at doses which can elicit hypothermia antagonized head twitch responses mediated by the central 5-HT_2 receptor. These results suggest that the chlorpromazine-and haloperidol-induced hypothermia may be mediated by the blockade of the central 5-HT_2 receptor.
- 社団法人日本薬学会の論文
- 1995-11-15
著者
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山田 潤
神戸薬科大学 薬理
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堀坂 和敬
Department Of Pharmacology Kobe Pharmaceutical University
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杉本 由美
神戸薬科大学、薬理学研究室
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山田 潤
Department of Pharmacology, Kobe Pharmaceutical University
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杉本 由美
Department of Pharmacology, Kobe Pharmaceutical University
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Yamada J
Kobe Pharmaceutical Univ. Kobe Jpn
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山田 潤
Department Of Pharmacology Kobe Pharmaceutical University
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杉本 由美
Department of Ophthalmology, Faculty of Medical Science, University of Fukui
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