FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. I. ON THE HYPOLIPIDEMIC EFFECTS

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The effects of L-ascorbate 2-sulfate (AAS) on the lipid metabolism were examined in Triton-induced hyperlipemic mice, hyper cholesterolemic and normal rats, the following results being obtained. 1) In Triton-induced hyperlipemic mice, AAS (300mg/kg) significantly decreased the serum cholesterol level, while L-ascorbate (AA, 175mg/kg) was found ineffective. 2) In hypercholesterolemic rats fed 0.5 % cholester ol diet, the consecutive administration of AAS decreased the level of serum cholesterol and liver triacylglycerols. AA only slightly affected these levels. However, both AAS and AA prevented the unordinal increase in the liver weight caused by cholesterol feeding. 3) In normal rats, the administration of AAS over a 4-week period decreased the level of serum cholesterol and liver triacylglycerols.
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