柴胡剤の薬理学的研究(第6報)小柴胡湯のD-Galactosamine肝障害ラットに対する作用

概要

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The effect of Shosaiko-to on the liver injury induced by D-galactosamine was studied in rats. Shosaiko-to (200 mg/kg, i.p.) suppressed markedly increases in serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) activities and decreases in hepatic tryptophan pyrrolase and glutamine synthetase activities induced by D-galactosamine The histopathological changes such as hyaline degeneration in the liver of rats injected D-galactosamine were reduced by Shosaiko-to. Daisaiko-to and Saikokeishi-to also suppressed the increase in serum GPT activity induced by D-galactosamine treatment. The active principles of Shosaiko-to were found in fraction which was adsorbed on Amberlite XAD-2 in H_2O and eluted with ethanol. The effect of Shosaiko-to on the increase in serum GPT activity was not observed in adrenalectomized rats. From these results, it was suggested that Shosaiko-to suppressed liver injury induced by D-galactosamine and the action of Shosaiko-to might involve in increase in adrenal function.
公益社団法人日本薬学会の論文
1984-07-25