4-Methylthiophenyl Dipropyl Phosphateの毒性とその一般薬理作用

概要

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The relationship between the toxicity and anti-cholinesterase action of 4-methylthiophenyl dipropyl phosphate (propaphos) was investigated. Oral administration of propaphos induced tremor or convulsion at a dose above 50 mg/kg in mice and at higher dose the lethal effect of propaphos was observed dose-dependently. The LD_<50> was 104 (96-113) mg/kg. Propaphos inhibited blood acetylcholinesterase activity of mice at low dose (25 mg/kg), while brain acetylcholinesterase activity was not affected by the dose but reduced by large dose of propaphos (100-150 mg/kg) markedly. These results suggested that the lethal action of propaphos may be closely associated with the inhibition of brain acetylcholinesterase activity. Further, propaphos was tested on general pharmacological actions in mice, rats, guinea pigs and rabbits, and the results were as follows : (1) Propaphos did not show remarkable central actions in mice when administered orally. (2) In in vitro experiments, propaphos showed non-specific inhibitory effect on the contraction induced by several agents in rat diaphragm and atria, ileum and trachea smooth muscle of guinea pig.
社団法人日本薬学会の論文
1984-04-25