柴胡剤の薬理学的研究(第1報)柴胡剤の摘出平滑筋に対する作用

概要

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Effects of basic (BASE) and additional (A, B, C) prescriptions in Saiko-prescriptions on the isolated smooth and cardiac muscles of rats and guinea-pigs were examined. All of BASE, A, B and C showed unequivocal anti-acetylcholine and anti-histamine actions in the isolated guinea-pig ileum. The simultaneous application of BASE and each addition showed more potent anti-acetylcholine and anti-histamine actions. BASE and BASE+A also had strong anti-barium ion action. The noradrenaline-induced contraction of isolated guinea-pig vas deferens was inhibited by BASE, A and BASE+A, whereas it was potentiated by B, C, BASE+B and BASE+C. Thus the inhibitory effect of BASE on this tissue was abolished in the presence of B or C. The spontaneous motility of isolated rat uterus was enhanced by BASE, but it was inhibited by A, B and BASE+A. The heart rates in spontaneous beating atria of guinea-pigs were reduced by B, C, BASE+A, BASE+B and BASE+C, but was not by A.
公益社団法人日本薬学会の論文
1982-04-25