The Effects of Peripheral Serotonin_2 (5-HT_2) and Serotonin_3 (5-HT_3) Receptor Agonists on Blood Glucose Levels in Rats

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概要

• 論文の詳細を見る

• The involvement of the peripheral serotonin_<2A> (5-HT_<2A>) receptor in α-methyl-5-HT-induced hyperglycemia was examined in rats. The 5-HT_<2A> receptor antagonist, ketanserin, significantly inhibited α-methyl-5-HT-elicited hyperglycemia. Taken together with a previous report that 5-HT-induced hyperglycemia was prevented by ketanserin, it is suggested that the periperal 5-HT_<2A> receptor participates in glucose regulation. As α-methyl-5-HT increased serum insulin but did not affect glucagon levels, it is indicated that these pancreatic hormones are probably not related to α-methyl-5-HT-induced hyperglycemia. Moreover, the peripheral 5-HT_3 receptor agonist, 2-methyl-5-HT, did not affect blood glucose, insulin or glucagon levels. Our results therefore suggest that the peripheral 5-HT_3 receptor is not involved in glucose regulation.

• 公益社団法人日本薬学会の論文
• 1996-10-15

著者

• 山田 潤

  神戸薬科大学 薬理

• YAMADA Jun

  Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo

• 杉本 由美

  神戸薬科大学、薬理学研究室

• Sugimoto Yoshihiko

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• SUGIMOTO Yumi

  Department of Pharmacology, Kobe Pharmaceutical University

• Sugimoto Y

  Dep. Of Pharmacology Kobe Pharmaceutical Univ.

• Sugimoto Yumi

  Department Of Pharmacology Kobe Pharmaceutical University

• Sugimoto Yumi

  Laboratory Of Pharmacology Department Of Clinical Pharmacy Yokohama College Of Pharmacy:department O

• Yamada J

  Kobe Pharmaceutical Univ. Kobe Jpn

• YOSHIKAWA Tomoko

  Department of Industrial Chemistry, Faculty of Engineering, Seikei University

• Sugimoto Yoko

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• 山田 潤

  Department Of Pharmacology Kobe Pharmaceutical University

• Yoshikawa T

  Institute For Medicinal Resources University Of Tokushima

• HORISAKA Kazuyoshi

  Department of Pharmacology, Kobe Pharmaceutical University

• Horisaka Kazuyoshi

  Department Of Pharmacology Kobe Pharmaceutical University

• 杉本 由美

  Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University

• Sugimoto Yumi

  Dep. Of Pharmacology Kobe Pharmaceutical Univ.

• Sugimoto Yumi

  Department Of Pharmacology Kobe Women's College Of Pharmacy.

• Yamada J

  Lab. Of Pharmacology Dep. Of Clinical Pharmacy Yokohama Coll. Of Pharmacy

• Sugimoto Y

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• Yamada Jun

  Department Of Pharmacology Kobe Pharmaceutical University

• Yoshikawa T

  Kitasato Univ. Kanagawa Jpn

• Yoshikawa Tomoko

  Department Of Biology University Of Virginia

• Yamada Jun

  Department Of Electrical And Electronics Engineering Aichi Institute Of Technology

• Yoshikawa Tetsushi

  Laboratory Of Virology Research Institute For Disease Mechanism And Control Nagoya University Graduate School Of Medicine

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