Inhibitory Effects of the 5-HT_<1A> Receptor Agonist Buspirone on Stress-Induced Hyperglycemia in Mice : Involvement of Insulin and a Buspirone Metabolite, 1-(2-Pyrimidinyl) piperazine (1-PP)(Pharmacology)

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概要

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• Effects of serotonergic anxiolytic buspirone on immobilization-induced hyperglycemia were studied in mice. Stress elicited hyperglycemia in mice. Pretreatment with buspirone significantly reduced immobilization-induced hyperglycemia. Buspirone increased serum insulin levels in both non- and stressed mice. The major metabolite of buspirone, 1-(2-pyrimidinyl)piperazine (1-PP) also increased and this further inhibited immobilization-induced hyperglycemia, since 1-PP increased serum insulin levels in both non-stressed and stressed mice, similar to the increases induced by buspirone. These results suggest that buspirone can reduce stress-induced hyperglycemia by facilitating insulin release. Moreover, 1-PP, a metabolite of buspirone may participate in the effects of buspirone. Since 1-PP is an antagonist of α_2 receptors, α_2 receptors may be related to effects of 1-PP.

• 公益社団法人日本薬学会の論文
• 2005-04-01

著者

• 山田 潤

  神戸薬科大学 薬理

• YAMADA Jun

  Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo

• 杉本 由美

  神戸薬科大学、薬理学研究室

• Sugimoto Yoshihiko

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• SUGIMOTO Yumi

  Department of Pharmacology, Kobe Pharmaceutical University

• Sugimoto Y

  Dep. Of Pharmacology Kobe Pharmaceutical Univ.

• Sugimoto Yumi

  Department Of Pharmacology Kobe Pharmaceutical University

• Sugimoto Yumi

  Laboratory Of Pharmacology Department Of Clinical Pharmacy Yokohama College Of Pharmacy:department O

• Yamada J

  Kobe Pharmaceutical Univ. Kobe Jpn

• Sugimoto Yoko

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• 山田 潤

  Department Of Pharmacology Kobe Pharmaceutical University

• NOMA Toshiko

  Department of Pharmacology, Kobe Pharmaceutical University

• Noma Toshiko

  Department Of Pharmacology Kobe Pharmaceutical University

• 杉本 由美

  Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University

• Sugimoto Yumi

  Dep. Of Pharmacology Kobe Pharmaceutical Univ.

• Sugimoto Yumi

  Department Of Pharmacology Kobe Women's College Of Pharmacy.

• TAKASHIMA Nozomu

  Department of Pharmacology, Kobe Pharmaceutical University

• Takashima Nozomu

  Department Of Pharmacology Kobe Pharmaceutical University

• Yamada J

  Lab. Of Pharmacology Dep. Of Clinical Pharmacy Yokohama Coll. Of Pharmacy

• Sugimoto Y

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• Yamada Jun

  Department Of Pharmacology Kobe Pharmaceutical University

• Yamada Jun

  Department Of Electrical And Electronics Engineering Aichi Institute Of Technology

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