FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. V. ON THE HYPOLIPIDEMIC AND ANTIATHEROSCLEROTIC EFFECTS OF L-ASCORBATE 2-SULFATE IN RABBITS
スポンサーリンク
概要
- 論文の詳細を見る
Effects of L-ascorbate 2-sulfate (AAS) on lipid metabolism and on pathological changes of aorta and visceral organs were investigated in cholesterol fed rabbits, with ascorbic acid (AA) and clofibrate (CPIB) as reference compounds. Administration of AAS (300 and 150 mg/kg) inhibited an increase in the levels of serum total cholesterol, free cholesterol, triglycerides and phospholipids caused by cholesterol feeding. A high dose of AAS prevented an increase of liver weight. An increase in the level of liver cholesterol was inhibited by a high dose of AAS. Both doses of AAS effectively prevented an accumulation of cholesterol in the aorta. The area rate of atheromatous plaque in aorta was less in specimens from both groups of AAS than in those from control I. Pathological changes in intima and media of aorta were milder in specimens from both groups of AAS. Development of pathological changes in arteries of various organs were prevented with both doses of AAS.
- 社団法人 日本薬理学会の論文
著者
-
Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
-
Terada Mamoru
Department Of Electrical Engineering Nagoya University
-
Hayashi Eiichi
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
-
Yamada Jun
Department Of Pharmacology Kobe Pharmaceutical University
-
SATO Masaru
Nippon Chemiphar Co., Ltd.
-
Yamada Jun
Department Of Electrical And Electronics Engineering Aichi Institute Of Technology
-
KUNITOMO Masaru
Department of Pharmacology, Shizuoka College of Pharmaceutical Sciences
-
TERADA Mamoru
Department of Pharmacology, Shizuoka College of Pharmaceutical Sciences
-
YAMADA Jun
Department of Pharmacology, Shizuoka College of Pharmaceutical Sciences
関連論文
- Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer
- Evaluation of Blood Pressure Measured by Tail-Cuff Methods (without Heating) in Spontaneously Hypertensive Rats(Pharmacology)
- Effects of Ginkgo Biloba Extract Feeding on Salt-Induced Hypertensive Dahl Rats(Pharmacology)
- Chronic Production of Peroxynitrite in the Vascular Wall Impairs Vasorelaxation Function in SHR/NDmcr-cp Rats, an Animal Model of Metabolic Syndrome
- Long-Term Feeding of Ginkgo biloba Extract Impairs Peripheral Circulation and Hepatic Function in Aged Spontaneously Hypertensive Rats(Pharmacognosy)
- P2Y Receptor-Mediated Ca^ Signaling Increases Human Vascular Endothelial Cell Permeability
- Pharmacology and Physiology of Perivascular Nerves Regulating Vascular Function : Purinergic Modulation of Vascular Sympathetic Neurotransmission
- Characterization of Prejunctional Purinoceptors Inhibiting Noradrenaline Release in Rat Mesenteric Arteries
- Activation of In Vivo Kupffer Cell Function by Oral Administration of Cordyceps sinensis in Rats
- Peroxynitrite-Generating Species: Good Candidate Oxidants in Aqueous Extracts of Cigarette Smoke
- Regional Differences in Noradrenaline-Induced Release of Adenosine Triphosphate from Rat Vascular Endothelium
- The 5-HT_2 Receptor Antagonist Reduces Immobility of Mice Treated with the Atypical Antidepressant Mianserin in the Forced Swimming Test
- EFFECT OF PIPERIDINE AND RELATED ALICYCLIC AMINES ON NICOTINIC AND MUSCARINIC AGONIST BINDING SITES IN THE MAMMALIAN BRAIN
- Oxidants in the Gas Phase of Cigarette Smoke Pass Through the Lung Alveolar Wall and Raise Systemic Oxidative Stress
- EFFECT OF SHAKUYAKU-KANZOH-TOH, A PRESCRIPTION COMPOSED OF SHAKUYAKU (PAEONIAE RADIX) AND KANZOH (GLYCYRRHIZAE RADIX) ON GUINEA PIG ILEUM
- In vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their interactions with chloroquine
- Dietary Corosolic Acid Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice(Pharmacognosy)
- Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation
- Early gastric cancer with Krukenberg tumor and review of cases of intramucosal gastric cancers with Krukenberg tumor
- The Tricyclic Antidepressant Clomipramine Increases Plasma Glucose Levels of Mice
- Involvement of Serotonin in Zimelidine-Induced Hyperglycemia in Mice
- Effects of Peripheral Administration of 5-Hydroxytryptamine (5-HT) on 2-Deoxy-D-glucose-Induced Hyperphagia in Rats(Pharmacology)
- The 5-HT^ Receptor Agonist m-Chlorophenylpiperazine(mCPP)Inhibits 2-Deoxy-D-glucose(2-DG)-Induced Hyperphagia in Rats
- Effects of a Nitric Oxide Synthase Inhibitor on Hypophagia Induced by the Peripheral 5-HT Receptor Agonists, α-Methyl-5-hydroxytryptamine and 5-Carboxamidotryptamine in Rats
- Inhibitory Effects of a Nitric Oxide Synthase Inhibitor, N^G-Nitro-L-arginine Methyl Ester (L-NAME), on 2-Deoxy-D-glucose-Induced Hyperglycemia in Rats
- The Effects of Peripheral Serotonin_2 (5-HT_2) and Serotonin_3 (5-HT_3) Receptor Agonists on Blood Glucose Levels in Rats
- Involvement of Leptin in Hypophagia Induced by the Serotonin Precursor 5-Hydroxytryptophan (5-HTP) in Mice(Pharmacology)
- Inhibitory Effects of the 5-HT_ Receptor Agonist Buspirone on Stress-Induced Hyperglycemia in Mice : Involvement of Insulin and a Buspirone Metabolite, 1-(2-Pyrimidinyl) piperazine (1-PP)(Pharmacology)
- Effects of the Serotonergic Anxiolytic Buspirone on Plasma Glucose and Glucose-Induced Hyperglycemia in Mice
- Effects of Insulin and Adrenalectomy on Elevation of Serum Leptin Levels Induced by 5-Hydroxytryptophan in Mice(Pharmacology)
- Leptin Inhibits Food Intake without Affecting Brain NOx Levels in Food-Deprived Mice(Pharmacology)
- SIMULTANEOUS DETERMINATION OF TRYPTOPHAN AND ITS METABOLITES IN BIOLOGICAL SAMPLES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH FLUOROMETRIC DETECTION
- EFFECTS OF ω-AMINOSULFONIC ACIDS ON LIPID METABOLISM IN DIETARY HYPERLIPIDEMIC RATS
- EFFECT OF TRYPTAMINE ON THE BEHAVIOR OF MICE
- ELEVATION OF SERUM INDOLEACETIC ACID LEVELS IN RATS WITH EXPERIMENTAL LIVER FAILURE
- INDOLEACETIC ACID-INDUCED HYPOTHERMIA AND CHANGES IN SEROTONIN METABOLISM IN MICE
- The 5-HT_1A Receptor Agonist 8-Hydroxy-2-di-n-(propylamino)tetralin(8-OH-DPAT)Induces Hyperglucagonemia in Rats
- Seasonal variation in the content of a febrifugine and isofebrifugine alkaloid mixture in aerial parts of Hydrangea macrophylla var. Otaksa, with special reference to its antimalarial activity
- A Potent antimalarial activity of Hydrangea macrophylla var. Otaksa leaf extract against Plasmodium yoelii 17XL in mice
- Study on Physical Properties of Plasma Generated by YAG Laser in Liquid
- Intraperitoneal administration of paclitaxel solubilized with poly(2-methacryloxyethyl phosphorylcholine-co n-butyl methacrylate) for peritoneal dissemination of gastric cancer
- POSSIBILITIES FOR ADENOSINE MODULATION OF PERISTALTIC REFLEX IN GUINEA PIG ISOLATED ILEUM
- Effects of albendazole against larval and adultAngiostrongylus cantonensis in rats
- Participation of Endogenous Noradrenaline in the Relaese of ATP by High Potassium in the Rat Caudal Artery
- Sex Differences in Enzyme Activities Relating to Cholesteryl Ester Metabolism in Aorta and Liver from SHRSP, SHR, and WKR during aging
- Al, Cu and W Oxide Fine Particles Produced by Discharge Explosions
- The Printing Mask for Electron Diffraction Photographs
- THE INFLUENCE OF EXTRACELLULAR Ca2+ CONCENTRATION ON THE INHIBITORY EFFECT OF ADENOSINE IN GUINEA-PIG ILEAL LONGITUDINAL MUSCLES
- Effects of the 5-HT_2 Receptor Antagonist, Ritanserin on Hyperthermia and Depletion of 5-HT in Frontal Cortex Induced by a 5-HT Releasing Drug, p-Chloroamphetamine(PCA)in Mice
- IN VIVO EVALUATION OF COMBINATION EFFECTS OF CHLOROQUINE WITH CEPHARANTHIN^【○!R】OR MINOCYCLINE HYDROCHLORIDE AGAINST BLOOD-INDUCED CHLOROQUINE-RESISTANT PLASMODIUM BERGHEI NK 65 INFECTIONS
- Dissecting Aneurysm of the Middle Cerebral Artery Manifesting as Subarachnoid Hemorrhage and Hemorrhagic Infarctions : Case Report
- THE DYSFUNCTIONS OF PLATELETS FROM STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS (SHRSP) : DEFECTS IN THROMBIN-INDUCED PROTEIN PHOSPHORYLATION
- Pressure Dependence of Carbon Film Coating by a Toroidal Methane Discharge
- STUDIES ON CHEMOTHERAPY OF PARASITIC HELMINTHS (VIII). EFFECTS OF SOME POSSIBLE NEUROTRANSMITTERS ON THE MOTILITY OF ANGIOSTRONGYLUS CANTONENSIS
- STUDIES ON CHEMOTHERAPY OF PARASITIC HELMINTHS (VII). EFFECTS OF VARIOUS CHOLINERGIC AGENTS ON THE MOTILITY OF ANGIOSTRONGYLUS CANTONENSIS
- STUDIES ON CHEMOTHERAPY OF PARASITIC HELMINTHS (VI) EFFECTS OF VARIOUS NEUROPHARMACOLOGICAL AGENTS ON THE MOTILITY OF DIPYLIDIUM CANINUM
- Genetic analysis of mortality in murine angiostrongyliasis costaricensis using SMXA recombinant inbred mouse strains
- Effects of Amorphous and Polymorphs of PF1022A, a New Antinematode Drug, on Angiostrongylus costaricensis in Mice
- EXPERIMENTAL ATHEROSCLEROSIS IN RATS FED A VITAMIN D, CHOLESTEROL-RICH DIET
- Toxicologic Investigation of Dimethylacrylamide in Mice
- FUNDAMENTAL STUDIES OF ANTHELMINTICS (XXII). ELECTROPHYSIOLOGICAL STUDIES OF 1-[2-(DODECYLOXY) ETHYL]PYRROLIDINE HYDROCHLORIDE (DEP) ON ASCARIS MUSCLE CELLS
- COMPARATIVE STUDIES ON ANTI-NICOTINIC ACTION OF HEXAMETHONIUM, MECAMYLAMINE AND ADENOSINE IN THE GUINEA PIG ISOLATED ILEUM
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. VI. EFFECTS OF L-ASCORBATE 2-SULFATE ON LIPID METABOLISM IN GUINEA PIGS
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. V. ON THE HYPOLIPIDEMIC AND ANTIATHEROSCLEROTIC EFFECTS OF L-ASCORBATE 2-SULFATE IN RABBITS
- EFFECTS OF SURUGATOXIN ON ADRENERGICALLY INNERVATED TISSUES
- Impedance of a Partially Ionized Cecium Plasma
- EFFECT OF PICROTOXIN ON ADRENAL CATECHOLAMINE SECRETION
- EFFECTS OF NICOTINIC RECEPTOR AGONISTS AND ANTAGONISTS ON UPTAKE AND EFFLUX OF 45Ca IN PERFUSED BOVINE ADRENAL GLANDS
- Spasmogenic effects of L-ascorbic acid on the guinea pig isolated ileum preparation.
- Changes by hypertension and hypercholesterolemia in arterial enzyme activities in the rat
- Effects of Cholesterol Loading on Autoimmune MRL-lpr/lpr Mice. Susceptibility to Hypercholesterolemia and Aortic Cholesterol Deposition.
- Pharmacological Analysis of Receptors Involved in the Late, Tachykininergic Contractile Response to Electrical Transmural Stimulation in Isolated Rabbit Iris Sphincter Muscle.
- Possible Participation of ATP in Changes of Blood Pressure in SHR and Old Rats
- Hyperlipidemic effects of adriamycin in rats.
- Suppression of adjuvant arthritis in rats by cholesterol.
- Abnormal lipid metabolism in adjuvant arthritic rats.
- Enhancing activity of anthranilic acid on adjuvant arthritis in rats and antibody formation in mice.
- Cholesterol reduces and corticosteroids enhance the toxicity of vitamin D in rats.
- P2Y Receptor-Mediated Ca2+ Signaling Increases Human Vascular Endothelial Cell Permeability
- Changes in Platelet Functions due to Hypertension in The Rat VI. Comparison of Experimental Hypertension with Spontaneous Hypertension
- Alterations in Renal α and β-Adrenoceptors in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP)
- Changes in platelet function due to hypertension. Appearance of "exhausted" platelets due to long duration of hypertension and stroke
- A Uniform Alteration in Serum Lipid Metabolism Occurring during Inflammation in Mice.
- Inhibition by chlorpromazine, metals and I-ascorbic acid of calcium-ATPase and magnesium-ATPase in bovine adrenal medullary microsomes.
- Reduced .ALPHA.2-adrenoceptor binding in lower brainstem of stroke-prone spontaneously hypertensive rats.
- Reciprocal alteration in cardiac and hypothalamic adrenergic receptors in spontaneously hypertensive rats
- Central Acetylcholine Receptors in Spontaneously Hypertensive Rats
- Effects of adenosine on contractile response of circular muscle in electrically stimulated guinea-pig ileum.
- Changes in aortic lysosomal enzyme activities by DOCA-salt and renal hypertension in the rat-comparison with spontaneous hypertension
- Effects of hypertension superimposed by hypercholesterolemia on arterial enzyme activities in SHRSP
- Lipid deposition in the aorta of adjuvant arthritic rats with hypercholesterolemia.
- Cholesterol metabolism in serum and aorta of inbred mice fed a high-cholesterol diet.
- Impairment of Endothelium-Dependent Relaxation in Aorta from Rats with Arteriosclerosis Induced by Excess Vitamin D and a High-Cholesterol Diet.
- Effect of 2,4,6-trinitrophenol on catecholamine secretion from perfused bovine adrenal glands.
- Abnormalities in platelet function in stroke prone spontaneously hypertensive rats (SHRSP)
- The Change in Lipid Hydrolase Activities during Aging in the Aorta from SHRSP, SHR, and WKR
- Effects of hypotensive treatment on platelet aggregation in SHRSP
- Altered Vasoconstrictor Responsiveness in Vitamin D-Induced Arteriosclerotic Rat Aortas.
- Atherosclerosis mouse model induced by a high-cholesterol diet supplemented with .BETA.-aminopropionitrile: Effects of various anti-atherosclerotic agents on the biochemical parameters.
- Elective Treatment of Middle Colic Artery Aneurysm