STUDIES ON CHEMOTHERAPY OF PARASITIC HELMINTHS (VI) EFFECTS OF VARIOUS NEUROPHARMACOLOGICAL AGENTS ON THE MOTILITY OF <I>DIPYLIDIUM CANINUM</I>

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概要

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• Effects of various neuropharmacological agents on the motility of <I>Dipylidium caninum</I> were studied. 5-HT stimulated the motility of D. caninum, while other drugs such as GABA, adrenaline, phenylephrine, isoproterenol, dibenamine, and propranolol showed little effect. The stimulatory action of 5-HT was antagonized by tryptophol. Stibnal caused paralysis which was blocked by the pretreatment with 5-HT. Paralytic effects were caused by eserine, dichlorovos, ACh, carbachol and DMPP, but not by pilocarpine and McN-A-343. d-Tubocurarine, hexamethonium, and atropine all showed little effect on the motility and on the paralytic action of eserine. Though guanidine showed little effect, strychnine remarkably stimulated the motility. The action of strychnine was stimulated by 5-HT but partially inhibited by tryptophol. Morphine and picrate slightly stimulated the motility, but showed little influence on the paralytic action of eserine. These two agents stimulated the paralyzed preparation by tryptophol transiently and sustainedly, respectively. These results on the cholinergic and serotonergic drugs basically showed good agreement with those reported in trematodes such as <I>Schistosoma mansoni</I> and <I>Fasciola hepatica.</I>

• 社団法人 日本薬理学会の論文

著者

• ISHII Akira

  Department of Medical Zoology, Jichi Medical School

• KINO Hideto

  Department of Parasitology, Hamamatsu University School of Medicine

• TERADA Mamoru

  Department of Parasitology, Hamamatsu University School of Medicine

• Kino Hideto

  Department Of Parasitology Hamamatsu University School Of Medicine

• Terada Mamoru

  Department Of Electrical Engineering Nagoya University

• SANO Motohito

  Department of Parasitology, Hamamatsu University School of Medicine

• Ishii Akira

  Department Of Angiology And Cardiology Kitasato University Graduate School Of Medical Sciences

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