Silyl Linker-based Approach to the Solid-phase Synthesis of Fmoc Glycopeptide Thioesters(Organic Chemistry)
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概要
- 論文の詳細を見る
An efficient solid-phase synthesis of Fmoc (glyco)peptide thioesters is described. Fmoc・Ser・OAll and Fmoc・Thr・OAll bound to resin with a silyl ether linker were deallylated by Pd(0) catalysis and condensed with thiophenol, benzyl mercaptane, and ethyl 3-mercaptopropionate by activation with DCC/HOBt. The thioesters were released from the resin either by treatment with CsF-AcOH or by acidic hydrolysis. The effectiveness of this silyl linker strategy is further demonstrated by the synthesis of more complex (glyco)peptide thioesters 25, 26 and 27 involving N→C and C→N peptide elongation.
- 社団法人日本農芸化学会の論文
- 2002-02-23
著者
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Ito Yukishige
The Institute Of Physical And Chemical Research (riken)
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ISHII Akira
Department of Medical Zoology, Jichi Medical School
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NAKAHARA Yuko
The Institute of Physical and Chemical Research (RIKEN)
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Nakahara Yoshiaki
Department Of Applied Biochemistry Faculty Of Engineering Tokai University
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Ishii A
Department Of Applied Biochemistry Faculty Of Engineering Tokai University
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Ito Yukishige
Riken Advanced Science Institute
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Hojo H
Department Of Applied Biochemistry Institute Of Glycoscience Tokai University
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Hojo Hironobu
Department Of Applied Biochemistry Faculty Of Engineering Tokai University
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Ishii Akira
Department Of Angiology And Cardiology Kitasato University Graduate School Of Medical Sciences
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Ishii Akira
Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine
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