Synthesis of a Glycosylated Peptide Thioester by the Boc Strategy and Its Application to Segment Condensation

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概要

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• The synthesis of a chitobiosylated peptide thioester by the t-butoxycarbonyl (Boc) strategy is demonstrated. Boc-Asn carrying benzyl-protected chitobiose was introduced during application of the Boc mode solid-phase method. HF treatment of the resulting protected peptide resin gave the desired chitobiosylated peptide thioester. This thioester was used to prepare the peptide sequence derived from extracellular matrix metalloproteinase inducers (emmprin) (34-94), (34-118) and (22-118) by the thioester segment condensation method. The conformation of these glycopeptides is characterized by circular dichroism (CD) spectral measurement.

• 社団法人 日本農芸化学会の論文
• 2006-06-23

著者

• Toole B

  The Medical University Of South Carolina

• HAGINOYA Eiichiro

  Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University

• HOJO Hironobu

  Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University

• NAKAHARA Yuko

  Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University

• NAKAHARA Yoshiaki

  Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University

• NABESHIMA Kazuki

  Fukuoka University School of Medicine

• TOOLE Bryan

  The Medical University of South Carolina

• WATANABE Yasushi

  National Food Research Institute

• Nabeshima K

  Miyazaki Medical Coll. Miyazaki Jpn

• Nakamura Yu

  Nissei Hospital

• Nakahara Yoshiaki

  Department Of Applied Biochemistry Faculty Of Engineering Tokai University

• Nakahara Y

  Tokai Univ. Kanagawa Jpn

• Haginoya Eiichiro

  Department Of Applied Biochemistry Institute Of Glycotechnology Tokai University

• Nakahara Y

  Department Of Applied Biochemistry Institute Of Glycoscience Tokai University

• Hojo H

  Department Of Applied Biochemistry Institute Of Glycoscience Tokai University

• Hojo Hironobu

  Department Of Applied Biochemistry Faculty Of Engineering Tokai University

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