Coordinated Expression of MMPs in Pathfinder Cells and Reorganization of Extracellular Matrix during Cohort Migration
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概要
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Migration of tumor cells is usually assessed as single cell locomotion in vitro using Boyden chamber type assays. In vivo, however, carcinoma cells frequently invade the surronding tissue as coherent clusters or nests of cells. We have called this type of movement cohort migration and developed a two-dimensional in vitro cohort migration model, in which human colon carcinoma cells move as coherent cell sheets when stimulated with hepatocyte growth factor/scatter factor (HGF/SF). In this model, we have demonstrated that cohort migration has two unique features : first, temporal disruption of cell-cell adhesion is compartmentalized to the lower portion of cells, which allows the cells to extend leading lamella ; second, cell-cell contact in the coherent migrating cell sheets regulates expression and localization of proteins used for migration, such as gelatinase A (MMP-2) and membrane-type 1-matrix metalloproteinase (MT1-MMP), to work predominantly at the front of the migrating cell sheets. Gelatin matrix was reorganized to suit cell migration via this leading-lamella-of-pathfinder-cell-specific localization of MT1-MMP and MMP-2 during cohort migration, and this reoganization was essential for this type of migration. These lines of evidence suggest that cohort migration is a specific mode of cell migration, and thus we now consider that not only single-cell locomotion but also cohort migration could be involved in carcinoma-cell invasion : the former mainly in poorly differentiated carcinomas while the latter in well to moderately differentiated carcinomas.
- 日本結合組織学会の論文
- 2001-12-25
著者
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Nabeshima Kazuki
Department of Pathology, Faculty of Medicine, Fukuoka University
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NABESHIMA Kazuki
Fukuoka University School of Medicine
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Nabeshima K
Miyazaki Medical Coll. Miyazaki Jpn
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Nabeshima Kazuki
Department Of 2nd Pathology Miyazaki Medical College
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