Solid-Phase Synthesis of Core 8 O-Glycan-Linked MUC5AC Glycopeptide

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概要

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• The benzyl-protected disaccharide building blocks of core 8 O-glycan (15a/15b) for glycopeptide were stereoselectively synthesized by two glycosidation reactions with the glycosyl fluoride method. The building blocks were utilized in the solid-phase synthesis of a glycopeptide carrying two O-glycans with the consensus sequence of the tandem-repeat domain of MUC5AC. The synthetic glycopeptide was detached from the resin with reagent K, and subsequent debenzylation under conditions of low-acidity TfOH afforded glycopeptide 2. The synthetic sample will be used as a suitable standard in studies of the physicochemical or immunochemical characterization of mucin glycoforms.

• 社団法人 日本農芸化学会の論文

著者

• HOJO Hironobu

  Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University

• NAKAHARA Yuko

  Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University

• NAKAHARA Yoshiaki

  Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University

• Maemura Makoto

  Departmetn of Surgery, Faculty of Medicing, Kagoshima Unibersity

• Nakahara Yoshiaki

  Department Of Applied Biochemistry Faculty Of Engineering Tokai University

• Maemura Makoto

  Departmetn Of Surgery Faculty Of Medicing Kagoshima Unibersity

• OHGAKI Atsushi

  Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University

• Nakahara Y

  Department Of Applied Biochemistry Institute Of Glycoscience Tokai University

• Hojo Hironobu

  Department Of Applied Biochemistry Faculty Of Engineering Tokai University

• MAEMURA Makoto

  Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University

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