STUDIES ON CHEMOTHERAPY OF PARASITIC HELMINTHS (VII). EFFECTS OF VARIOUS CHOLINERGIC AGENTS ON THE MOTILITY OF <I>ANGIOSTRONGYLUS CANTONENSIS</I>

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概要

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• Effects of various cholinergic agents on the motility of <I>Angiostrongylus cantonensis</I> were studied to define the neuropharmacological properties of this worm. Stimulation of the motility and/or contraction were shown by eserine, ACh, carbachol, nicotine, DMPP, pyrantel, and Ba<SUP>2+</SUP>, but not by pilocarpine and McN-A-343. Contraction was similarly observed by these agents in the preparations paralyzed with praziquantel. Paralysis was caused remarkably by d-tubocurarine and slightly by succinylcholine, while the contraction induced by eserine and DMPP was little influenced by these drugs. Both the motility and the eserine-induced contraction were little influenced by hexamethonium, but stimulated remarkably by atropine. Though hemicholinium-3, morphine, and picrate showed little effect, guanidine stimulated remarkably the motility and also the eserine-induced contraction. The stimulatory action of guanidine was antagonized by strychnine. Strychnine paralyzed the motility, and the eserine-induced contraction was antagonized by the pre and post-treatment with strychnine. From these results, it is suggested that the excitatory cholinergic mechanism in A. cantonensis is nicotinic, and it is basically similar to that reported in <I>Ascaris suum.</I>

• 社団法人 日本薬理学会の論文

著者

• ISHII Akira

  Department of Medical Zoology, Jichi Medical School

• KINO Hideto

  Department of Parasitology, Hamamatsu University School of Medicine

• TERADA Mamoru

  Department of Parasitology, Hamamatsu University School of Medicine

• Kino Hideto

  Department Of Parasitology Hamamatsu University School Of Medicine

• Terada Mamoru

  Department Of Electrical Engineering Nagoya University

• SANO Motohito

  Department of Parasitology, Hamamatsu University School of Medicine

• Ishii Akira

  Department Of Angiology And Cardiology Kitasato University Graduate School Of Medical Sciences

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