Spasmogenic effects of L-ascorbic acid on the guinea pig isolated ileum preparation.
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概要
- 論文の詳細を見る
The mechanism of actions of L-ascorbic acid (AA) on the guinea pig isolated ileum was studied. AA (neutralized, 10<SUP>-3</SUP> M) produced a stimulated motility (A effect) and a potentiation in acetylcholine (ACh) -induced contraction (B effect). The A effect showed a tachyphylaxis, and was inhibited by tetrodotoxin, atropine, adenosine, morphine, strychnine, Mg<SUP>2+</SUP>, papaverine and glucose- and Ca<SUP>2+</SUP>-free medium, but was stimulated by eserine. Thus, AA appears to have not only a direct myogenic effect but also a neurogenic effect by stimulating ACh release from intramural cholinergic nerves.
- 公益社団法人 日本薬理学会の論文
著者
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HAYASHI EIICHI
Department of Pharmacology, Shizuoka College of Pharmaceutical Sciences
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Terada Mamoru
Department Of Electrical Engineering Nagoya University
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Hayashi Eiichi
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
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Hayashi Satoru
Department Of Dermatology Faculty Of Medicine University Of Yamanashi
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HAYASHI Satoru
Department of Pharmacology, Shizuoka College of Pharmaceutical Sciences
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HAYASHI Satoru
Department of Chemical Engineering, Nagoya University
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