EFFECTS OF SURUGATOXIN ON ADRENERGICALLY INNERVATED TISSUES
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概要
- 論文の詳細を見る
Effects of surugatoxin (SGTX), a new ganglionic blocking agent on adrenergically innervated tissues: guinea pig isolated atria and vas deferens were investigated. SGTX (1, 10 μM) markedly reduced the cardiostimulatory response of the atria to nicotine and also partially the response to 1, 1-dimethyl-4-phenylpiperazinium (DMPP) and 5-hydroxvtrvptamine, without affecting responses to noradrenaline, tyramine and histamine. The contractile response of the vas deferens to nicotine, DMPP and hypogastric nerve stimulation was markedly reduced by SGTX (1, 10 μM), whereas that to noradrenaline, acetylcholine and transmural stimulation was not affected. These results indicate that SGTX has an antagonistic action on nicotinic receptors in these tissues as well as in sympathetic ganglia and in guinea pig ileum.
- 社団法人 日本薬理学会の論文
著者
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Yamada Shizuo
Department Of Biophamacy School Of Pharmaceutical Sciences University Of Shizuoka
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Hayashi Eiichi
Department Of Pharmacology Shizuoka College Of Pharmaceutical Sciences
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YAMADA Shizuo
Department of Pharmacology, Shizuoka College of Pharmaceutical Sciences
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