Effects of Repeated Morphine Treatment on the Antinociceptive Effects, Intestinal Absorption, and Efflux from Intestinal Epithelial Cells of Morphine
スポンサーリンク
概要
- 論文の詳細を見る
The present study was conducted to investigate the effects of repeated treatment with morphine on the drugs antinociceptive effects, intestinal absorption, and transepithelial transport. The antinociceptive effects of morphine in rats were markedly decreased after repeated oral administration of the drug for 5 d, indicating the development of tolerance. In the morphine-tolerant rats, intestinal absorption of morphine was determined using the in situ loop method. Absorption of morphine from the jejunum was significantly decreased after repeated administration. The permeability of human intestinal epithelial Caco-2 cells was increased in the efflux direction after repeated treatment. The repeated administration of morphine also reduced the cellular accumulation and efflux of P-glycoprotein substrates ([3H]vincristine and rhodamine123) from Caco-2 cells, suggesting that it enhances P-glycoprotein-mediated efflux in Caco-2 cells. These results suggest that repeated use enhances the efflux of morphine in the epithelial cells of the small intestine, subsequently decreasing its intestinal absorption.
- 公益社団法人 日本薬学会の論文
著者
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KAGAWA Yoshiyuki
Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University
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Kato Yoshihisa
Department of Internal Medicine, Fujita-Gakuen University School of Medicine
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Kato Yoshihisa
Department Of Internal Medicine School Of Medicine Fujita Health Univ.
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YAMADA Shizuo
Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) Program, S
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KIMURA Midori
Department of Physiology, St. Marianna University School of Medicine
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Kimura Midori
Department Of Pharmacokinetics And Pharmacodynamics And Global Center Of Excellence (coe) And Clinic
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OKURA Takashi
Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) and Clinic
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OZAWA Tadahiro
Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) and Clinic
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Kagawa Yoshiyuki
Department Of Clinical Pharmaceutics And Pharmacy Practice Faculty Of Pharmaceutical Sciences Univer
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Yamada Shizuo
Department Of Biophamacy School Of Pharmaceutical Sciences University Of Shizuoka
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Ibe Michiko
Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE), School of
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Taki Yuko
Department of Pharmacokinetics, Pharmacodynamics, Global Center of Excellence (COE) and Clinical Pha
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Taki Yuko
Department Of Pharmacokinetics And Pharmacodynamics And Global Center Of Excellence (coe) Program Sc
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Yamada Shizuo
Department of Pharmacokinetics, Pharmacodynamics, Global Center of Excellence (COE) and Clinical Pharmaceutics, University of Shizuoka School of Pharmaceutical Sciences
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Okura Takashi
Department of Pharmacokinetics, Pharmacodynamics, Global Center of Excellence (COE) and Clinical Pharmaceutics, University of Shizuoka School of Pharmaceutical Sciences
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Ibe Michiko
Department of Pharmacokinetics, Pharmacodynamics, Global Center of Excellence (COE) and Clinical Pharmaceutics, University of Shizuoka School of Pharmaceutical Sciences
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Kato Yoshihisa
Department of Pharmacokinetics, Pharmacodynamics, Global Center of Excellence (COE) and Clinical Pharmaceutics, University of Shizuoka School of Pharmaceutical Sciences
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Taki Yuko
Department of Pharmacokinetics, Pharmacodynamics, Global Center of Excellence (COE) and Clinical Pharmaceutics, University of Shizuoka School of Pharmaceutical Sciences
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Kagawa Yoshiyuki
Department of Pharmacokinetics, Pharmacodynamics, Global Center of Excellence (COE) and Clinical Pharmaceutics, University of Shizuoka School of Pharmaceutical Sciences
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Kagawa Yoshiyuki
Department of Clinical Pharmaceutics & Pharmacy Practice, Graduate School of Pharmaceutical Sciences, University of Shizuoka
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Kimura Midori
Department of Pharmacokinetics, Pharmacodynamics, Global Center of Excellence (COE) and Clinical Pharmaceutics, University of Shizuoka School of Pharmaceutical Sciences
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