Combined Antitumor Effect of Cyclophosphamide and Bromodeoxyuridine in BDF1 Mice Bearing L1210 Ascites Tumors(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the combined effect of cyclophosphamide (CPA) and 5-bromo-2'-deoxyuridine (BrdUrd) both in mice bearing L1210 ascites tumors and in L1210 leukemic cells in vitro. Administration of BrdUrd (100mg/kg) for 5 consecutive days before a single dose (80mg/kg) of CPA significantly extended the survival of mice by 158%, compared with CPA alone. BrdUrd administered at daily doses of 100 or 200mg/kg for 5 consecutive days did not extended the survival of mice. An in vitro MTT assay revealed that BrdUrd enhanced the cytotoxic effect of 4-hydroxycyclophosphamide, an active form of CPA, in the L1210 cells. These results indicate that BrdUrd enhanced the antitumor effect of CPA both in vivo and in vitro.
- 公益社団法人日本薬学会の論文
- 2008-01-01
著者
-
KOMADA Yoshihiro
Department of Pediatrics, Mie University
-
KAGAWA Yoshiyuki
Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University
-
Komada Yoshihiro
Department Of Pediatrics
-
Kagawa Yoshiyuki
Department Of Clinical Pharmaceutics And Pharmacy Practice Faculty Of Pharmaceutical Sciences Univer
-
Kagawa Yoshiyuki
Department Of Clinical Pharmaceutics School Of Pharmaceutical Sciences University Of Shizuoka
-
HIGASHIGAWA MASAMUNE
Department of Pediatrics, Mie University School of Medicine
-
Higashigawa Masamune
Department Of Pediatrics Mie University School Of Medicine
-
NOGE Ichiro
Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka
-
Noge Ichiro
Department Of Clinical Pharmaceutics School Of Pharmaceutical Sciences University Of Shizuoka
-
KOMADA Yoshihiro
Department of Pediatrics, Mie University School of Medicine
-
Kagawa Yoshiyuki
Department of Clinical Pharmaceutics & Pharmacy Practice, Graduate School of Pharmaceutical Sciences, University of Shizuoka
-
Noge Ichiro
Department of Clinical Pharmaceutics & Pharmacy Practice, Graduate School of Pharmaceutical Sciences, University of Shizuoka
関連論文
- リアルタイムPCR法を用いた乳児の唾液および母乳中のサイトメガロウイルス核酸量の検討
- The Impact of Total Bilirubin on Plasma Micafungin Levels in Living-Donor Liver Transplantation Recipients with Severe Liver Dysfunction(Biopharmacy)
- Outcome after Relapse in Childhood Acute Lymphoblastic Leukemia
- Prognostic Factors in Childhood Acute Lymphoblastic Leukemia in Japan
- PHARMACOKINETICS AND CLINICAL EFFECTS OF CEFOZOPRAN IN PEDIATRIC PATIENTS
- Relationship between Development of Nephrotoxicity and Blood Concentration of Cyclosporine A in Bone-Marrow Transplanted Recipients Who Received the Continuous Intravenous Infusion(Pharmacology)
- Plasma concentration of itraconazole and its antifungal prophylactic efficacy in patients with neutropenia after chemotherapy for acute leukemia
- Enhancement by Grapefruit Juice of Morphine Antinociception(Pharmacology)
- Prediction of α_1-Adrenoceptor Occupancy in the Human Prostate from Plasma Concentrations of Silodosin, Tamsulosin and Terazosin to Treat Urinary Obstruction in Benign Prostatic Hyperplasia(Pharmacology)
- EFFECT OF PIPERIDINE AND RELATED ALICYCLIC AMINES ON NICOTINIC AND MUSCARINIC AGONIST BINDING SITES IN THE MAMMALIAN BRAIN
- Clinical and Genetic Characterisitics of Japanese Burkitt Lymphomas with or without Leukemic Presentation
- PE-510 Bosentan Promotes Incorporation of Bone Marrow-Derived Endothelial Progenitor Cells but Inhibits Infiltration of Macrophages in Mice Exposed to Chronic Hypoxia(PE086,Pulmonary Circulation (H),Poster Session (English),The 73rd Annual Scientific Meet
- Elevated Levels of C-reactive Protein Late after Kawasaki Disease : an Association between Inflammation and Late Coronary Sequelae in Kawasaki Disease(Congenital Heart Disease/Kawasaki's Disease 1 (M), The 69th Annual Scientific Meeting of the Japanese Ci
- Influence of Metal Cations on Plasma Trough Concentration of Mycophenolic Acid and Its Glucuronide in Tacrolimus-Treated and Cyclosporine-Treated Kidney Transplant Recipients(Biopharmacy)
- Effects of Calcineurin Inhibitors on Pharmacokinetics of Mycophenolic Acid and Its Glucuronide Metabolite during the Maintenance Period Following Renal Transplantation(Pharmacology)
- Persistent lung shadow in an infant with ventricular septal defect and partial anomalous pulmonary venous connection associated with pulmonary venous obstruction
- Congenital Bilateral Diaphragmatic Eventration with Membranous Chest Wall Hamartoma
- OE-323 Role of High Mobility Group Box 1 in Monocrotaline-induced Pulmonary Hypertension in Rats(Pulmonary circulation-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-291 Incorporation of Bone Marrow-derived Cells into Pulmonary Vascular Lesions in Mice Exposed to Chronic Hypoxia : Endothelial Cells and Fibroblasts(Pulmonary circulation-3 (H) PE49,Poster Session (English),The 70th Anniversary Annual Scientific Meeti
- Emergent Permanent Pacemaker Implantation in a Premature 1,502g Neonate
- A Nuclear Factor K B Inhibitor Ameliorated Pulmonary Hypertension and Pulmonary Vascular Remodeling in Rats
- Novel Therapeutic Approaches against Experimental Pulmonary Hypertension by Targeting Endothelial Cell-Related Signaling Pathways and Regeneration
- Transplantation of human umbilical cord blood-derived endothelial progenitor cells to pulmonary circulation in nude mice associated with pulmonary hypertension
- Specific gene transfer targeting the pulmonary circulation by using a novel hemagglutinating virus of Japan envelope vector in rats
- Onset of Clinical Effects and Plasma Concentration of Fluvoxamine in Japanese Patients
- Effects of Cigarette Smoking and Cytochrome P450 2D6 Genotype on Fluvoxamine Concentration in Plasma of Japanese Patients
- Detection of adenovirus DNA in clinical samples by SYBR Green real-time polymerase chain reaction assay
- Apoptotic cell death of human T lymphoblastoid cells induced by arginine deiminase
- A case of metastatic ovarian non-gestational choriocarcinoma : Successful treatment with conservative type surgery and myeloablative chemotherapy
- Clinical Efficacy of Therapeutic Drug Monitoring in Patients Receiving Vancomycin
- Clinical features of measles in immunocompromised children
- Heat-resistant Properties in Autoclaving of New Polycarbonate Bottles Containing a Disinfectant of Chlorhexidine Digluconate Solution
- Effects of Repeated Morphine Treatment on the Antinociceptive Effects, Intestinal Absorption, and Efflux from Intestinal Epithelial Cells of Morphine
- Plasma, Intestine and Tumor Levels of 5-Fluorouracil in Mice Bearing L1210 Ascites Tumor Following Oral Administration of 5-Fluorouracil, UFT(Mixed Compound of Tegafur and Uracil), Carmofur and 5'-Deoxy-5-fluorouridine
- Increased Deoxycytidine Kinase Activity by Etoposide in L1210 Murine Leukemic Cells
- Effect of Etoposide on the Influx and Intracellular Accumulation of Cytosine Arabinoside in Human and Murine Leukemic Cell Lines and in Human Peripheral Leukemic Cells
- Effect of Etoposide on Cell Cycle Progression in L1210 Murine Ascites Tumor
- A New Diabetic Mouse Model Derived from the ddY Strain
- Vaccine-associated paralytic poliomyelitis in an infant with perianal abscesses
- Role of Ca^ in the Intracellular Signaling Pathway of Anti-IgM : Induced Apoptosis in the Human B-Cell Line, MBC-1, Established from Burkitt Lymphoma
- Pharmacokinetic and Pharmacodynamic Analysis of Acetylcholinesterase Inhibition by Distigmine Bromide in Rats
- Combined Antitumor Effect of Cyclophosphamide and Bromodeoxyuridine in BDF1 Mice Bearing L1210 Ascites Tumors(Pharmacology)
- Viral Load in Epstein-Barr Virus-Associated Hemophagocytic Syndrome
- Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide
- Apoptosis of human peripheral blood mononuclear cells by wild-type measles virus infection is induced by interaction of hemagglutinin protein and cellular receptor, SLAM via caspase-dependent pathway
- Cell cycle dependency of caspase activation in Fas-induced apoptosis in leukemia cells
- Expression of short-form caspase 8 correlates with decreased sensitivity to Fas-mediated apoptosis in neuroblastoma cells
- Functional immaturity of cord blood monocytes as detected by impaired response to hepatocyte growth factor
- False-Positive Plasma (1→3)-β-D-Glucan Test following Immunoglobulin Product Replacement in an Adult Bone Marrow Recipient
- Infantile spontaneous spinal epidural hematoma
- Immunological unresponsiveness and apoptotic cell death of T cells in measles virus infection
- An infantile case of cytomegalovirus induced idiopathic thrombocytopenic purpura with predominant proliferation of CD10 positive lymphoblast in bone marrow
- Dizygotic twins with neonatal alloimmune neutropenia associated with maternal anti-human neutrophil antigen-1b antibody
- Elevated Von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting a poor outcome
- Flow cytometric analysis of de novo acute lymphoblastic leukemia in childhood : report from the Japanese Pediatric Leukemia/Lymphoma Study Group
- Flow cytometric analysis of de novo acute myeloid leukemia in childhood : report from the Japanese Pediatric Leukemia/Lymphoma Study Group
- Acute motor-sensory axonal Guillain-Barre syndrome with unilateral facial nerve paralysis after rotavirus gastroenteritis in a 2-year-old boy
- Release Profiles of Dexamethasone Dipropionate from Admixtures of Steroid and Heparinoid Ointments Prepared by Different Mixing Methods
- Errata: The Impact of Total Bilirubin on Plasma Micafungin Levels in Living-Donor Liver Transplantation Recipients with Severe Liver Dysfunction [Biol. Pharm. Bull. 32(4): 750-754 (2009)]
- Influence of Concomitant Antiepileptic Drugs on Plasma Lamotrigine Concentration in Adult Japanese Epilepsy Patients
- Infiltration of M1 macrophages into adipose tissue of ddY-H mice preceding spontaneous appearances of insulin resistance
- Hepatic Steatosis with Relation to Increased Expression of Peroxisome Proliferator-Activated Receptor-γ in Insulin Resistant Mice
- Particle Condition Change in Emulsion Admixture Evaluated by in Situ Flow Particle Imaging Analysis
- Simultaneous occurrence of gastric antral vascular ectasia and protein-losing enteropathy in chronic graft-versus-host disease