Enhancement by Grapefruit Juice of Morphine Antinociception(Pharmacology)

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概要

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• The aim of this study was to investigate the effect of grapefruit juice intake on the antinociception of morphine in rats. The antinociception of morphine (30mg/kg, per os (p.o.)) was significantly enhanced by the oral administration of grapefruit juice (2ml/rat). Further, the effect of grapefruit juice was examined in morphine-tolerant rats. The repeated administration of morphine (100mg/kg p.o.) for 5d caused a marked decrease in the antinociception, indicating the development of morphine-tolerance. In the morphine-tolerant rats, oral administration of grapefruit juice potentiated significantly the antinociceptive effect of morphine. To examine the pharmacokinetics of morphine after the repeated treatment with morphine for 5d, microdialysis probes were implanted into the jugular vein and spinal intrathecal space in rats. The morphine concentrations in the blood and intrathecal cerebrospinal fluid (CSF) were gradually decreased by the repeated treatment with morphine. The grapefruit juice treatment significantly increased the blood concentration of morphine in morphine-tolerant rats. These results suggest that oral administration of grapefruit juice enhances the morphine antinociception by increasing the intestinal absorption of this agent.

• 2008-12-01

著者

• Ito Yoshihiko

  Department of Molecular Science and Technology, Doshisha University

• KAGAWA Yoshiyuki

  Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University

• YAMADA Shizuo

  Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) Program, S

• Yamada Shizuo

  Departments Of Pharmacokinetics And Pharmacodynamics Pharmacognosy And Global Center Of Excellence (

• KIMURA Midori

  Department of Physiology, St. Marianna University School of Medicine

• Kimura Midori

  Department Of Pharmacokinetics And Pharmacodynamics And Global Center Of Excellence (coe) And Clinic

• Yamada S

  School Of Pharmaceutical Sciences And Coe21 University Of Shizuoka

• Yamada Shizuo

  Department Of Pharmacokinetics And Pharmacodynamics And Global Center Of Excellence (coe) And Clinic

• Yamada S

  Department Of Biopharmacy University Of Shizuoka School Of Pharmaceutical Sciences

• OKURA Takashi

  Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) and Clinic

• OZAWA Tadahiro

  Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) and Clinic

• Kagawa Yoshiyuki

  Department Of Pharmacokinetics And Pharmacodynamics And Global Center Of Excellence (coe) And Clinic

• Kagawa Yoshiyuki

  Department Of Clinical Pharmaceutics And Pharmacy Practice Faculty Of Pharmaceutical Sciences Univer

• Ito Yoshihiko

  Department Of Pharmacokinetics And Pharmacodynamics And Global Center Of Excellence (coe) And Clinic

• Yamada Shizuo

  Department Of Biophamacy School Of Pharmaceutical Sciences University Of Shizuoka

• Ito Yoshihiko

  Department Of Mathematics Faculty Of Education Kumamoto University

• Kagawa Yoshiyuki

  Department Of Pharmacokinetics And Pharmacodynamics Global Center Of Excellence (coe) And Clinical P

• Okura Takashi

  Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) and Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka

• Ozawa Tadahiro

  Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) and Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka

• Kagawa Yoshiyuki

  Department of Clinical Pharmaceutics & Pharmacy Practice, Graduate School of Pharmaceutical Sciences, University of Shizuoka

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