A 12-month Feeding Study of Reproduction/Development in Rats Fed Meat/Milk Powder Supplemented Diets Derived from the Progeny of Cloned Cattle Produced by Somatic Cell Nuclear Transfer
スポンサーリンク
概要
- 論文の詳細を見る
The present 12-month feeding study was carried out with rat groups fed a diet supplemented with meat or milk (meat/milk) derived from the progeny of clones produced by somatic cell nuclear transfer (SCNT) technology. It was conducted to obtain data concerning the chronic toxicities of these edible products during the process of development and reproduction in rats fed such products. The rats were subjected to clinical observations for general health condition and examinations such as sensory/reflex function, grip strength, motor activity, body weight, food consumption, ophthalmology and urinalysis. Moreover, sexually matured rats fed the test diets were mated and examined for items such as the reproductive performances of the dams and health of their pups. After the feeding period, factors related to rat health status, based on the findings for hematology, blood biochemistry, necropsy, organ weight and histology, were examined. There were no biologically significant differences in these factors between the rat groups fed meat/milk powder supplemented diets derived from the progeny and those fed meat/milk powder supplemented diets derived from conventionally bred cattle. Therefore, the present chronic toxicity study suggests that meat and milk derived from the progeny of SCNT cattle might be equivalent to those derived from conventionally bred cattle in use as dietary supplements for rats.
- 日本繁殖生物学会の論文
- 2008-10-01
著者
-
Ito Yoshihiko
Department of Molecular Science and Technology, Doshisha University
-
WATANABE Shinya
National Institute of Livestock and Grassland Science
-
Yamaguchi Makiko
Department Of Toxicology Research Institute For Animal Science In Biochemistry And Toxicology
-
Yamaguchi Makiko
Department Of Internal Medicine Kyoto First Red Cross Hospital
-
Ito Yoshihiko
Department Of Toxicology Research Institute For Animal Science In Biochemistry And Toxicology
-
ITOH Masaya
Department of Toxicology, Research Institute for Animal Science in Biochemistry and Toxicology
-
Ito Yoshihiko
Department Of Mathematics Faculty Of Education Kumamoto University
-
Itoh Masaya
Department Of Toxicology Research Institute For Animal Science In Biochemistry And Toxicology
関連論文
- Palladium-catalyzed 1,2-addition of alkylborane reagents to aldehydes
- The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: Bladder Selectivity Based on In Vivo Drug–Receptor Binding Characteristics of Antimuscarinic Agents for Treatment of Overactive Bladder
- Pharmacologically Relevant Receptor Binding Characteristics and 5α-Reductase Inhibitory Activity of Free Fatty Acids Contained in Saw Palmetto Extract(Pharmacology)
- Langmuir-Blodgett films of helical rigid-rod poly(quinoxaline-2,3-diyl)s
- Comparison of the Growth Performances of Offspring Produced by a Pair of Cloned Cattle and Their Nuclear Donor Animals
- Structure-Activity Relationships of Receptor Binding of 1,4-Dihydropyridine Derivatives(Pharmacology)
- Isolation and Pharmacological Characterization of Fatty Acids from Saw Palmetto Extract
- Enhancement by Grapefruit Juice of Morphine Antinociception(Pharmacology)
- Asymmetric 1,4-Addition Reaction of Arylboronic Acid to Eneone Catalyzed by Palladium with Ferrocene-based Phosphine Ligand
- Palladium Catalyzed Conjugate 1,4-Addition of Organoboronic Acids to α,β-Unsaturated Ketones
- Palladium-Catalyzed Coupling Reactions of N-Methoxy-N-methylcarbamoyl Chloride for the Synthesis of N-Methoxy-N-methylamides
- Regio-and Stereoselective Incorporation of a ^C Nuclide into D-ribo-Phytosphingosine via SmI_2-Mediated C-C Formation with ^C-Labeled Isocyanide
- Preparation of (Alkaneimidoyl)lanthanides and Their Reactions with Carbonyl Compounds
- Alkyllithium-Mediated Anomalous Trimerization of 2,6-Xylyl Isocyanide
- Reduction of α,β-Unsaturated Ketones with Diphenylsilanes Bearing Several Substituents on Their Phenyl Moiety Catalyzed by Rhodium-Phosphine Complexes
- Trans-Chelating Chiral Peralkyldiphosphine Ligands (R,R)-(S,S)-2,2''- Bis[1-(dialkylphosphino)ethyl]-1,1''-biferrocenes (AlkylTRAPs) and Their Transition Metal Complexes
- Racemization and Deracemization of Poly(quinoxaline-2,3-diyl)s
- Health Status and Productive Performance of Somatic Cell Cloned Cattle and Their Offspring Produced in Japan
- PB33 ASYMMETRIC SYNTHESIS OF β-HYDROXYL-α-AMINO ACIDS BY ASYMMETRIC ALDOL REACTION OF α-ISOCYANOCARBOXYLATES CATALYZED BY CHIRAL FERROCENYLPHOSPHINE-GOLD (I) COMPLEXES
- PB64 INTRAMOLECULAR HYDROSILATION : A NEW STEREOCONTROLLED SYNTHETIC METHOD IN CARBOHYDRATE CHEMISTRY
- A 12-month Feeding Study of Reproduction/Development in Rats Fed Meat/Milk Powder Supplemented Diets Derived from the Progeny of Cloned Cattle Produced by Somatic Cell Nuclear Transfer
- Catalytic Asymmetric Hydrogenation of α-(Acetamido)acrylates Using TRAP Trans-Chelating Chiral Bisphosphine Ligands: Remarkable Effects of Ligand P-Substituent and Hydrogen Pressure on Enantioselectivity
- Asymmetric Hydrosilylation of Ketones Using Trans-Chelating Chiral Peralkylbisphosphine Ligands Bearing Primary Alkyl Substituents on Phosphorus Atoms
- Synthesis and Structural Analysis of Oligo(naphthalene-2, 3-diyl)s
- Comparison of the Growth Performances of Offspring Produced by a Pair of Cloned Cattle and Their Nuclear Donor Animals
- A Novel Missense Mutation of the MEN1 Gene in a Multiple Endocrine Neoplasia Type 1 Patient Associated with Carcinoid Syndrome
- Stereoselective Synthesis via Palladium-Catalyzed Intramolecular Bis-Silylation
- Pharmacokinetic and Pharmacodynamic Analysis of Acetylcholinesterase Inhibition by Distigmine Bromide in Rats
- Demonstration of Muscarinic and Nicotinic Receptor Binding Activities of Distigmine to Treat Detrusor Underactivity
- Rhodium-Catalyzed Enantioselective Michael Addition of (1-Cyanoethyl)phosphonate: Synthesis of Optically Active Phosphonic Acid Derivatives with Phosphorus-Substituted Quaternary Asymmetric Carbon Center
- The Effect of Ovary Storage and In Vitro Maturation on mRNA Levels in Bovine Oocytes; A Possible Impact of Maternal ATP1A1 on Blastocyst Development in Slaughterhouse-derived Oocytes
- Hydrogenation of Five-Membered Heteroaromatic Compounds Catalyzed by a Rhodium-Phosphine Complex
- Reactions of Si-Si σ-Bonds with Bis(t-alkyl isocyanide)palladium(0) Complexes. Synthesis and Reactions of Cyclic Bis(organosilyl)palladium Complexes
- Death losses due to stillbirth, neonatal death and diseases in cloned cattle derived from somatic cell nuclear transfer and their progeny : a result of nationwide survey in Japan
- Synthesis of a Bis (Silyl) iridium (III) Complex via Oxidative Addition of an Si-Si Linkage to Ir (I) and Its Crystal Structure
- A Note on Blocks and Defect Groups of a Finite Group
- A Silyl Substituent Dictates the Pathway of a Concerted Electrocyclic Ring-opening of Cyclobutene
- The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction : Bladder Selectivity Based on In Vivo Drug-Receptor Binding Characteristics of Antimuscarinic Agents for Treatment of Overactive Bladder
- Ruthenium-Mediated Domino Sequence Forming Six-Membered Ring Diene from Ene-Yne and Alkene
- DNA methylation analysis on satellite I region in blastocysts obtained from somatic cell cloned cattle
- The Effect of Ovary Storage and In Vitro Maturation on mRNA Levels in Bovine Oocytes : A Possible Impact of Maternal ATP1A1 on Blastocyst Development in Slaughterhouse-derived Oocytes
- Survival of embryos and calves derived from somatic cell nuclear transfer in cattle : a nationwide survey in Japan
- Beneficial Effects of Gosha-jinki-gan and Green Tea Extract in Rats With Chemical Cystitis
- Muscarinic Receptor Binding of the Novel Radioligand, [3H]Imidafenacin in the Human Bladder and Parotid Gland
- Bladder Endothelin-1 Receptor Binding of Bosentan and Ambrisentan
- Reactions of Nitrogen Oxides with Isocyanide
- Indole syntheses utilizing o-methylphenyl isocyanides.
- The Acid-catalyzed Reaction of Isocyanide with Oxetane
- Synthetic Reactions by Complex Catalysts. XXIV. A New Catalyst of Copper-Isocyanide Complex for the Michael Addition
- Synthetic Reactions by Complex Catalysts. XVI. The Dimerization of Acrylonitrile and Acrylate by Means of the Metal-Isocyanide Complex
- The Thermal Rearrangement and Degradation of 2,3-Bis(alkylimino)oxetane
- Synthesis of indole derivatives by Cu2O-catalyzed cyclization of o-(.ALPHA.-cyanoalkyl)phenyl isocyanides and o-[.ALPHA.-(methoxycarbonyl)alkyl]phenyl isocyanides.
- Synthetic Reactions by Complex Catalysts. XXVI. The Copper-catalyzed Reaction of α,β-Unsaturated Isocyanide with Active Methylene Compounds
- Synthetic Reactions by Complex Catalysts. XXV. The Copper-catalyzed Reaction of Allyl Isocyanide with Carbonyl Compounds and Olefins. Syntheses of 4-Vinyl-2-oxazoline and 5-Vinyl-1-pyrroline Derivatives
- Synthetic Reactions by Complex Catalysts XXVIII. Reaction of β-Propiolactone with Alkyl Halide Caused by Cu2O-Isonitrile Complex