Clinical Efficacy of Therapeutic Drug Monitoring in Patients Receiving Vancomycin
スポンサーリンク
概要
- 論文の詳細を見る
Efficacy of therapeutic drug monitoring (TDM) of vancomycin (VCM) was retrospectively investigated in 184 patients with methicillin-resistant Staphylococcus aureus (MRSA) infection. The incidence of nephrotoxicity was compared between the patients who received TDM practice (TDM group, n=73) and did not (non-TDM group, n=111). Creatinine clearance (CLcr) values decreased significantly after the VCM therapy in the non-TDM group (p<0.05). The patients with MRSA bacteremia or pneumonia were classified into two groups according to peak concentrations of VCM: above 25μg/ml (Group A: n=29) and below (Group B: n=24). Mean duration of VCM therapy (14.1d) in Group A was significantly shorter than that (27.0d) in Group B. Mean cumulative total VCM doses (13.3g) in Group A was significantly less than that (25.0g) in Group B. These results indicate that monitoring peak concentration is essential to obtain better clinical effects for VCM therapy, and that the peak concentration above 25μg/ml is more effective.
- 公益社団法人日本薬学会の論文
- 2003-06-01
著者
-
IWAMOTO Takuya
Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University
-
KAGAWA Yoshiyuki
Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University
-
Iwamoto Takuya
Department Of Hospital Pharmacy Mie University School Of Medicine
-
Iwamoto Takuya
Department Of Environmental And Molecular Medicine Mie University School Of Medicine
-
KOJIMA Michio
Department of Hospital Pharmacy, Mie University School of Medicine
-
Kagawa Yoshiyuki
Department Of Clinical Pharmaceutics And Pharmacy Practice Faculty Of Pharmaceutical Sciences Univer
-
Kagawa Yoshiyuki
Department Of Hospital Pharmacy Mie University School Of Medicine
-
Iwamoto Takuya
Department Of Clinical Pharmacy And Biopharmaceutics Mie University Graduate School Of Medicine
-
Kojima Michio
Department Of Hospital Pharmacy Mie University School Of Medicine
-
Iwamoto Takuya
Department of Advanced Science and Technology, Toyota Technological Institute, Nagoya 468-8511, Japan
-
Kagawa Yoshiyuki
Department of Clinical Pharmaceutics & Pharmacy Practice, Graduate School of Pharmaceutical Sciences, University of Shizuoka
関連論文
- 29-P1-141 ACMIA法によるタクロリムス血中濃度測定に及ぼす低ヘマトクリット値の影響(TDM/薬物動態,社会の期待に応える医療薬学を)
- P1-222 (R-)CHOP療法に伴う便秘の予防を目的とした酸化マグネシウムの投与開始時期に関する検討(一般演題 ポスター発表,がん薬物療法(副作用対策),医療薬学の創る未来 科学と臨床の融合)
- 30-A2-14-2 生体肝移植患者におけるタクロリムスの血中濃度/投与量比並びに使用量に及ぼすCYP3A5遺伝子多型の影響(薬物動態(基礎と臨床),社会の期待に応える医療薬学を)
- 21C-09 婦人科がん患者におけるカルボプラチン過敏症に影響を及ぼす背景因子の検討(がん薬物療法(副作用対策),来るべき時代への道を拓く)
- 29-C1-13-4 婦人科のパクリタキセル・カルボプラチン併用療法施行患者における末梢神経障害と背景因子に関する解析(がん薬物療法,社会の期待に応える医療薬学を)
- P-632 抗がん剤ダカルバジンの光遺伝毒性に関する検討(8.有害事象・副作用(基礎と臨床)3,医療薬学の未来へ翔(はばた)く-薬剤師の薬剤業務・教育・研究への能動的関わり-)
- 原発性肝がんに対するシスプラチン・リピオドール療法時の有害事象調査
- シクロスポリンA水性点眼液の院内製剤と新規市販製剤との文献による比較評価
- P1-267 がん疼痛緩和における薬剤師の認識に関する検討(一般演題 ポスター発表,がん薬物療法(緩和ケア),医療薬学の創る未来 科学と臨床の融合)
- P1-166 Gemcitabine+Fluorouracil+Cisplatin(GFP)療法によリ肝切除が可能となった切除不能肝内胆管癌の一症例(一般演題 ポスター発表,がん薬物療法(入院化学療法),医療薬学の創る未来 科学と臨床の融合)
- O9-002 ゾレドロン酸水和物投与患者における低カルシウム血症の危険因子に関する検討(一般演題 口頭発表,がん薬物療法/薬薬連携/薬学教育/地域・在宅医療,医療薬学の創る未来 科学と臨床の融合)
- S4-4 がん専門薬剤師が提言するがん薬物療法の安全管理(シンポジウム(日本薬剤学会ジョイントシンポジウム)S4 トランスポーター、レセプターから考えるがん治療の最前線,医療薬学の創る未来 科学と臨床の融合)
- The Impact of Total Bilirubin on Plasma Micafungin Levels in Living-Donor Liver Transplantation Recipients with Severe Liver Dysfunction(Biopharmacy)
- 21-P2-351 保険調剤薬局における医療用麻薬の取り扱いと服薬指導に関する実態調査 : 三重県下における実態把握と問題点の抽出(がん薬物療法(緩和ケア),来るべき時代への道を拓く)
- 21D-14 プロテアソーム阻害剤ボルテゾミブとイトラコナゾールの併用により著しい末梢神経障害と血小板減少を認めた3症例(薬物相互作用,来るべき時代への道を拓く)
- 29-P1-78 三重大学医学部附属病院における注射用抗菌薬の使用動向と後発医薬品への切り替えに伴う影響(感染制御・ICT,社会の期待に応える医療薬学を)
- 29-C1-13-3 原発性肝癌に対するシスプラチンリピオドール懸濁液の副作用調査および評価(がん薬物療法,社会の期待に応える医療薬学を)
- 29-C1-13-2 がん化学療法患者における発熱性好中球減少症に及ぼす栄養指標(血清アルブミン値、理想体重比)の影響(がん薬物療法,社会の期待に応える医療薬学を)
- 29-B2-13-5 Clostridium difficile陽性患者に対するバンコマイシン及びメトロニダゾールの治療における薬剤師の関与(服薬指導・薬剤管理指導,社会の期待に応える医療薬学を)
- 30-D-10 人工関節置換術後の慢性骨髄炎患者におけるバンコマイシン体内動態に関する検討 : 薬剤充填ハイドロキシアパタイト併用の影響(薬物動態(TDM・投与設計等),医療薬学の扉は開かれた)
- Churg-Strauss症候群の末梢神経痛に対してバルプロ酸ナトリウムが著効した症例
- P-2 アレルギー性肉芽腫性血管炎(Churg-Strauss症候群)の神経因性疼痛にバルプロ酸ナトリウムが著効した症例(1.薬物療法(基礎と臨床)1,医療薬学の未来へ翔(はばた)く-薬剤師の薬剤業務・教育・研究への能動的関わり-)
- シクロスポリンA水性点眼液の製剤学的検討と臨床適用
- 薬物動態学的アプローチによる薬物治療の安全確保への貢献
- P-566 当院における外来抗癌剤無菌調製業務の現状(14.調剤・処方管理・オーダリング(注射剤含む),"薬剤師がつくる薬物治療"-薬・薬・学の連携-)
- タクロリムスが有効であった重症筋無力症Osserman III型及びIIb型高齢者の2症例
- P1-293 鈴鹿中央総合病院における抗がん剤血管外漏出ラベルの作成と運用 : CS分析による評価(一般演題 ポスター発表,癌薬物療法(副作用対策),臨床から学び臨床へと還元する医療薬学)
- O3-05 低ナトリウム血症の誘発にかかるバルプロ酸血中濃度に関する検討(一般演題 口頭発表,薬物相互作用/有害事象・副作用,臨床から学び臨床へと還元する医療薬学)
- O5-07 生体肝移植患者のCYP3A5遺伝子多型が全血中タクロリムス濃度に及ぼす影響 : CLIA法とACMIA法の比較(一般演題 口頭発表,薬物動態・TDM・投与設計/薬物治療と遺伝子多型,臨床から学び臨床へと還元する医療薬学)
- Relationship between Development of Nephrotoxicity and Blood Concentration of Cyclosporine A in Bone-Marrow Transplanted Recipients Who Received the Continuous Intravenous Infusion(Pharmacology)
- Plasma concentration of itraconazole and its antifungal prophylactic efficacy in patients with neutropenia after chemotherapy for acute leukemia
- Enhancement by Grapefruit Juice of Morphine Antinociception(Pharmacology)
- Prediction of α_1-Adrenoceptor Occupancy in the Human Prostate from Plasma Concentrations of Silodosin, Tamsulosin and Terazosin to Treat Urinary Obstruction in Benign Prostatic Hyperplasia(Pharmacology)
- EFFECT OF PIPERIDINE AND RELATED ALICYCLIC AMINES ON NICOTINIC AND MUSCARINIC AGONIST BINDING SITES IN THE MAMMALIAN BRAIN
- Influence of Metal Cations on Plasma Trough Concentration of Mycophenolic Acid and Its Glucuronide in Tacrolimus-Treated and Cyclosporine-Treated Kidney Transplant Recipients(Biopharmacy)
- Effects of Calcineurin Inhibitors on Pharmacokinetics of Mycophenolic Acid and Its Glucuronide Metabolite during the Maintenance Period Following Renal Transplantation(Pharmacology)
- Onset of Clinical Effects and Plasma Concentration of Fluvoxamine in Japanese Patients
- Effects of Cigarette Smoking and Cytochrome P450 2D6 Genotype on Fluvoxamine Concentration in Plasma of Japanese Patients
- E24 Design Method for Structure of Injection Mold Fabricated by Metal Laser Sintering(Laser processing)
- DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect
- Distinct mechanisms of site-specific oxidative DNA damage by doxorubicin in the presence of copper(II) and NADPH-cytochrome P450,reductase
- がん薬物治療に伴う副作用の発現機構と要因分析に関する研究(日本医療薬学会奨励賞受賞講演,臨床から学び臨床へと還元する医療薬学)
- Clinical Efficacy of Therapeutic Drug Monitoring in Patients Receiving Vancomycin
- Heat-resistant Properties in Autoclaving of New Polycarbonate Bottles Containing a Disinfectant of Chlorhexidine Digluconate Solution
- Effects of Repeated Morphine Treatment on the Antinociceptive Effects, Intestinal Absorption, and Efflux from Intestinal Epithelial Cells of Morphine
- Plasma, Intestine and Tumor Levels of 5-Fluorouracil in Mice Bearing L1210 Ascites Tumor Following Oral Administration of 5-Fluorouracil, UFT(Mixed Compound of Tegafur and Uracil), Carmofur and 5'-Deoxy-5-fluorouridine
- Characterization of Powdered Drugs by UV Absorption Spectrum in the Hospital Pharmacy
- EFFECTS OF DISOPYRAMIDE ON THE MAXIMUM RATE OF RISE OF ACTION POTENTIAL (Vmax) IN GUINEA-PIG PAPILLARY MUSCLES
- A New Diabetic Mouse Model Derived from the ddY Strain
- Pharmacokinetic and Pharmacodynamic Analysis of Acetylcholinesterase Inhibition by Distigmine Bromide in Rats
- Combined Antitumor Effect of Cyclophosphamide and Bromodeoxyuridine in BDF1 Mice Bearing L1210 Ascites Tumors(Pharmacology)
- Elevated Systemic Elimination of Cimetidine in Rats with Acute Biliary Obstruction : The Role of Renal Organic Cation Transporter OCT2
- Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide
- Risk Factors Contributing to the Development of Hypocalcemia after Zoledronic Acid Administration in Patients with Bone Metastases of Solid Tumor
- Splenectomy enhances the anti-fibrotic effect of bone marrow cell infusion and improves liver function in cirrhotic mice and patients
- Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy
- Involvement of Specific Transport System on Uptake of Lactone Form of SN-38 in Human Intestinal Epithelial Cell Line Caco-2
- Evaluation of Basophil CD203c as a Predictor of Carboplatin-Related Hypersensitivity Reaction in Patients with Gynecologic Cancer
- Release Profiles of Dexamethasone Dipropionate from Admixtures of Steroid and Heparinoid Ointments Prepared by Different Mixing Methods
- Errata: The Impact of Total Bilirubin on Plasma Micafungin Levels in Living-Donor Liver Transplantation Recipients with Severe Liver Dysfunction [Biol. Pharm. Bull. 32(4): 750-754 (2009)]
- Multiple-Height Microstructure Fabricated by Deep Reactive Ion Etching and Selective Ashing of Resist Layer Combined with Ultraviolet Curing
- Influence of Concomitant Antiepileptic Drugs on Plasma Lamotrigine Concentration in Adult Japanese Epilepsy Patients
- Effect of transcatheter arterial infusion chemotherapy using iodized oil and degradable starch microspheres for hepatocellular carcinoma
- Infiltration of M1 macrophages into adipose tissue of ddY-H mice preceding spontaneous appearances of insulin resistance
- Hepatic Steatosis with Relation to Increased Expression of Peroxisome Proliferator-Activated Receptor-γ in Insulin Resistant Mice
- Clinical Application of Drug Delivery Systems in Cancer Chemotherapy: Review of the Efficacy and Side Effects of Approved Drugs
- Particle Condition Change in Emulsion Admixture Evaluated by in Situ Flow Particle Imaging Analysis
- Developmental changes in the levels of substrates for cholera toxin-catalyzed and pertussis toxin-catalyzed ADP-ribosylation in rat cardiac cell membranes.
- Splenectomy reduces fibrosis and preneoplastic lesions with increased thglycerides and essential fatty acids in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet